Abstract
Aim: The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC). Methods. Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC-SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated. Results: Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean BW-mean 18F-FDG PET PVC-SU-VBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 424-439 |
| Number of pages | 16 |
| Journal | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 58 |
| Issue number | 4 |
| Publication status | Published - Dec 1 2014 |
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Keywords
- Breast neoplasms
- Fluorodeoxyglucose F18
- Positron-emission tomography
- Prognosis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
Cite this
Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer. / Gallivanone, F.; Canevari, C.; Sassi, I.; Zuber, V.; Marassi, A.; Gianolli, L.; Picchio, M.; Messa, C.; Gilardi, M. C.; Castiglioni, I.
In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 58, No. 4, 01.12.2014, p. 424-439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer
AU - Gallivanone, F.
AU - Canevari, C.
AU - Sassi, I.
AU - Zuber, V.
AU - Marassi, A.
AU - Gianolli, L.
AU - Picchio, M.
AU - Messa, C.
AU - Gilardi, M. C.
AU - Castiglioni, I.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Aim: The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC). Methods. Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC-SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated. Results: Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean BW-mean 18F-FDG PET PVC-SU-VBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.
AB - Aim: The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC). Methods. Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC-SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated. Results: Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean BW-mean 18F-FDG PET PVC-SU-VBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.
KW - Breast neoplasms
KW - Fluorodeoxyglucose F18
KW - Positron-emission tomography
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84927960638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927960638&partnerID=8YFLogxK
M3 - Article
C2 - 24732679
AN - SCOPUS:84927960638
VL - 58
SP - 424
EP - 439
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
SN - 1824-4785
IS - 4
ER -