Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer

F. Gallivanone, C. Canevari, I. Sassi, V. Zuber, A. Marassi, L. Gianolli, M. Picchio, C. Messa, M. C. Gilardi, I. Castiglioni

Research output: Contribution to journalArticlepeer-review


Aim: The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC). Methods. Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC-SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated. Results: Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean BW-mean 18F-FDG PET PVC-SU-VBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.

Original languageEnglish
Pages (from-to)424-439
Number of pages16
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Issue number4
Publication statusPublished - Dec 1 2014


  • Breast neoplasms
  • Fluorodeoxyglucose F18
  • Positron-emission tomography
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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