Partial volume correction methods based on measured lesion-to-background ratio in PET-CT oncological studies

F. Gallivanone, A. Stefano, M. C. Gilardi, C. Messa, C. Canevari, I. Castiglioni

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study evaluates Operator-Dependent (OD) and Operator-Independent (OI) methods for Partial Volume effect Correction (PVC) in PET-CT oncological studies. The proposed PVC methods are based on curves of Recovery Coefficients (RC) versus Measured Lesion-to-Background ratios (M-L/B). NEMA IQ phantom PET-CT measurements were performed for RC curves estimation, for M-L/B from 2 to 30. Validation of the PVC methods was performed by 18F-FDG PET-CT studies of a Breast Oncological Phantom, miming from 1cm to 1.56 cm lesions in breasts, for prepared L/B from 14 to 54. An OI PVC method based on a threshold-technique for the estimation of lesion uptake was found the most accurate method (accuracy >80%). PVC methods were applied to the SUV quantification of 11 18F-FDG PET-CT oncological studies. Results prove PV strongly affects lesion quantification and needs to be corrected. When a decrement in the PET lesion volume is observed, PVC-SUV always decreased well fitting the clinical assessment, as from diagnostic report. When an increment in the PET lesion volume is observed, results suggest PVC-SUV should be used together with the PET lesion volume for a better characterization or therapy response of oncological lesions.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages360-363
Number of pages4
Volume25
Edition2
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
CountryGermany
CityMunich
Period9/7/099/12/09

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Keywords

  • PET-CT
  • PV
  • Quantification
  • RC

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Gallivanone, F., Stefano, A., Gilardi, M. C., Messa, C., Canevari, C., & Castiglioni, I. (2009). Partial volume correction methods based on measured lesion-to-background ratio in PET-CT oncological studies. In IFMBE Proceedings (2 ed., Vol. 25, pp. 360-363) https://doi.org/10.1007/978-3-642-03879-2-102