Participation of beta receptors in reflex vasodilatation in the dog

F. Rengo, B. Trimarco, G. Perez, M. Chiariello, L. de Caprio, L. Sacca, M. Condorelli

Research output: Chapter in Book/Report/Conference proceedingChapter


The effects of propranolol, given by direct intraarterial injection, on the reflex vasodilatation induced in the atropinized isolated gracilis muscle by rapid intravenous administration of norepinephrine, were studied in dogs. In these studies, neither atropine nor atropine plus propranolol significantly altered the maximum fall in vascular resistance in the perfused gracilis muscle following intravenous norepinephrine; however, if the reflex responses were evaluated as integrated areas of vasodilatation, atropine attenuated the vasodilatation and the administration of propranolol further attenuated the reflex. In fact, the value of the integrated areas of vasodilatation was 52.8 ± 9 mmHg/min in the basal state, 39 ± 6 mmHg/min after administration of atropine, and 24 ± 7 mmHg/min after propranolol, whereas the integrated areas of the systemic hypertension did not show any modification. These results prompt us to conclude that the adrenergic beta receptors participate in the reflex vasodilatation, although the mechanism of their action needs further elucidation.

Original languageEnglish
Title of host publicationAmerican Journal of Physiology
Number of pages4
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Medicine(all)


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