Participation of beta receptors in reflex vasodilatation in the dog

F. Rengo, B. Trimarco, G. Perez, M. Chiariello, L. de Caprio, L. Sacca, M. Condorelli

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Abstract

The effects of propranolol, given by direct intraarterial injection, on the reflex vasodilatation induced in the atropinized isolated gracilis muscle by rapid intravenous administration of norepinephrine, were studied in dogs. In these studies, neither atropine nor atropine plus propranolol significantly altered the maximum fall in vascular resistance in the perfused gracilis muscle following intravenous norepinephrine; however, if the reflex responses were evaluated as integrated areas of vasodilatation, atropine attenuated the vasodilatation and the administration of propranolol further attenuated the reflex. In fact, the value of the integrated areas of vasodilatation was 52.8 ± 9 mmHg/min in the basal state, 39 ± 6 mmHg/min after administration of atropine, and 24 ± 7 mmHg/min after propranolol, whereas the integrated areas of the systemic hypertension did not show any modification. These results prompt us to conclude that the adrenergic beta receptors participate in the reflex vasodilatation, although the mechanism of their action needs further elucidation.

Original languageEnglish
Title of host publicationAmerican Journal of Physiology
Pages1444-1447
Number of pages4
Volume230
Edition5
Publication statusPublished - 1976

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rengo, F., Trimarco, B., Perez, G., Chiariello, M., de Caprio, L., Sacca, L., & Condorelli, M. (1976). Participation of beta receptors in reflex vasodilatation in the dog. In American Journal of Physiology (5 ed., Vol. 230, pp. 1444-1447)