Abstract
The effects of propranolol, given by direct intraarterial injection, on the reflex vasodilatation induced in the atropinized isolated gracilis muscle by rapid intravenous administration of norepinephrine, were studied in dogs. In these studies, neither atropine nor atropine plus propranolol significantly altered the maximum fall in vascular resistance in the perfused gracilis muscle following intravenous norepinephrine; however, if the reflex responses were evaluated as integrated areas of vasodilatation, atropine attenuated the vasodilatation and the administration of propranolol further attenuated the reflex. In fact, the value of the integrated areas of vasodilatation was 52.8 ± 9 mmHg/min in the basal state, 39 ± 6 mmHg/min after administration of atropine, and 24 ± 7 mmHg/min after propranolol, whereas the integrated areas of the systemic hypertension did not show any modification. These results prompt us to conclude that the adrenergic beta receptors participate in the reflex vasodilatation, although the mechanism of their action needs further elucidation.
| Original language | English |
|---|---|
| Title of host publication | American Journal of Physiology |
| Pages | 1444-1447 |
| Number of pages | 4 |
| Volume | 230 |
| Edition | 5 |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Medicine(all)
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Participation of beta receptors in reflex vasodilatation in the dog. / Rengo, F.; Trimarco, B.; Perez, G.; Chiariello, M.; de Caprio, L.; Sacca, L.; Condorelli, M.
American Journal of Physiology. Vol. 230 5. ed. 1976. p. 1444-1447.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Participation of beta receptors in reflex vasodilatation in the dog
AU - Rengo, F.
AU - Trimarco, B.
AU - Perez, G.
AU - Chiariello, M.
AU - de Caprio, L.
AU - Sacca, L.
AU - Condorelli, M.
PY - 1976
Y1 - 1976
N2 - The effects of propranolol, given by direct intraarterial injection, on the reflex vasodilatation induced in the atropinized isolated gracilis muscle by rapid intravenous administration of norepinephrine, were studied in dogs. In these studies, neither atropine nor atropine plus propranolol significantly altered the maximum fall in vascular resistance in the perfused gracilis muscle following intravenous norepinephrine; however, if the reflex responses were evaluated as integrated areas of vasodilatation, atropine attenuated the vasodilatation and the administration of propranolol further attenuated the reflex. In fact, the value of the integrated areas of vasodilatation was 52.8 ± 9 mmHg/min in the basal state, 39 ± 6 mmHg/min after administration of atropine, and 24 ± 7 mmHg/min after propranolol, whereas the integrated areas of the systemic hypertension did not show any modification. These results prompt us to conclude that the adrenergic beta receptors participate in the reflex vasodilatation, although the mechanism of their action needs further elucidation.
AB - The effects of propranolol, given by direct intraarterial injection, on the reflex vasodilatation induced in the atropinized isolated gracilis muscle by rapid intravenous administration of norepinephrine, were studied in dogs. In these studies, neither atropine nor atropine plus propranolol significantly altered the maximum fall in vascular resistance in the perfused gracilis muscle following intravenous norepinephrine; however, if the reflex responses were evaluated as integrated areas of vasodilatation, atropine attenuated the vasodilatation and the administration of propranolol further attenuated the reflex. In fact, the value of the integrated areas of vasodilatation was 52.8 ± 9 mmHg/min in the basal state, 39 ± 6 mmHg/min after administration of atropine, and 24 ± 7 mmHg/min after propranolol, whereas the integrated areas of the systemic hypertension did not show any modification. These results prompt us to conclude that the adrenergic beta receptors participate in the reflex vasodilatation, although the mechanism of their action needs further elucidation.
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M3 - Chapter
VL - 230
SP - 1444
EP - 1447
BT - American Journal of Physiology
ER -