Abstract
It has been recognized that storage inflammation in organs of uraemic patients is due to silicone particle migration from tubing segments of the haemodialysis circuit to blood. Nevertheless, iatrogenic storage of foreign material containing Si has been also observed in long-term dialysis patients which, in our unit, used only PVC or PU-PVC tubings. The origin and the nature of the particulate has been investigated in vivo and in vitro on bioptical samples as well as on cuprophan dialyser and PVC tubing eluates. This study carried out by means of TEM, SEM and microprobe EDS revealed the presence of variously shaped material and particles containing Si in bioptical samples and in eluates. Si containing contaminants were not demonstrated in eluates filtered in absence of the dialyser. This result suggests that leachable products can result from the dialyser and that such release can be an additional risk for uraemic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 721-729 |
| Number of pages | 9 |
| Journal | Biomaterials, Artificial Cells, and Artificial Organs |
| Volume | 16 |
| Issue number | 4 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Particle migration from haemodialysis circuit : Electron microscopy and microprobe analysis. / Caiazza, S.; Giangrande, A.; Cantu, P.; Castiglioni, A.; Paoletti, L.; Donelli, G.
In: Biomaterials, Artificial Cells, and Artificial Organs, Vol. 16, No. 4, 1988, p. 721-729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Particle migration from haemodialysis circuit
T2 - Electron microscopy and microprobe analysis
AU - Caiazza, S.
AU - Giangrande, A.
AU - Cantu, P.
AU - Castiglioni, A.
AU - Paoletti, L.
AU - Donelli, G.
PY - 1988
Y1 - 1988
N2 - It has been recognized that storage inflammation in organs of uraemic patients is due to silicone particle migration from tubing segments of the haemodialysis circuit to blood. Nevertheless, iatrogenic storage of foreign material containing Si has been also observed in long-term dialysis patients which, in our unit, used only PVC or PU-PVC tubings. The origin and the nature of the particulate has been investigated in vivo and in vitro on bioptical samples as well as on cuprophan dialyser and PVC tubing eluates. This study carried out by means of TEM, SEM and microprobe EDS revealed the presence of variously shaped material and particles containing Si in bioptical samples and in eluates. Si containing contaminants were not demonstrated in eluates filtered in absence of the dialyser. This result suggests that leachable products can result from the dialyser and that such release can be an additional risk for uraemic patients.
AB - It has been recognized that storage inflammation in organs of uraemic patients is due to silicone particle migration from tubing segments of the haemodialysis circuit to blood. Nevertheless, iatrogenic storage of foreign material containing Si has been also observed in long-term dialysis patients which, in our unit, used only PVC or PU-PVC tubings. The origin and the nature of the particulate has been investigated in vivo and in vitro on bioptical samples as well as on cuprophan dialyser and PVC tubing eluates. This study carried out by means of TEM, SEM and microprobe EDS revealed the presence of variously shaped material and particles containing Si in bioptical samples and in eluates. Si containing contaminants were not demonstrated in eluates filtered in absence of the dialyser. This result suggests that leachable products can result from the dialyser and that such release can be an additional risk for uraemic patients.
UR - http://www.scopus.com/inward/record.url?scp=0023689683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023689683&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 721
EP - 729
JO - Biomaterials, Artificial Cells, and Artificial Organs
JF - Biomaterials, Artificial Cells, and Artificial Organs
SN - 0890-5533
IS - 4
ER -