Particulate air pollution and fasting blood glucose in nondiabetic individuals

Associations and epigenetic mediation in the normative aging study, 2000-2011

Cheng Peng, Marie Abele C Bind, Elena Colicino, Itai Kloog, Hyang Min Byun, Laura Cantone, Letizia Trevisi, Jia Zhong, Kasey Brennan, Alexandra E. Dereix, Pantel S. Vokonas, Brent A. Coull, Joel D. Schwartz, Andrea A. Baccarelli

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Among nondiabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among nondiabetic individuals. Objectives: Our goals were to investigate whether PM2.5 is associated with an increase in FBG and to explore potential mediating roles of epigenetic gene regulation. Methods: In 551 nondiabetic participants in the Normative Aging Study, we measured FBG, and DNA methylation of four inflammatory genes (IFN-γ, IL-6, ICAM-1, and TLR-2), up to four times between 2000 and 2011 (median = 2). We estimated short- and medium-term (1-, 7-, and 28-day preceding each clinical visit) ambient PM2.5 at each participant’s address using a validated hybrid land-use regression satellite-based model. We fitted covariate-adjusted regression models accounting for repeated measures. Results: Mean FBG was 99.8 mg/dL (SD = 10.7), 18% of the participants had impaired fasting glucose (IFG; i.e., 100–125 mg/dL FBG) at first visit. Interquartile increases in 1-, 7-, and 28-day PM2.5 were associated with 0.57 mg/dL (95% CI: 0.02, 1.11, p = 0.04), 1.02 mg/dL (95% CI: 0.41, 1.63, p = 0.001), and 0.89 mg/dL (95% CI: 0.32, 1.47, p = 0.003) higher FBG, respectively. The same PM2.5 metrics were associated with 13% (95% CI: –3%, 33%, p = 0.12), 27% (95% CI: 6%, 52%, p = 0.01) and 32% (95% CI: 10%, 58%, p = 0.003) higher odds of IFG, respectively. PM2.5 was negatively correlated with ICAM-1 methylation (p = 0.01), but not with other genes. Mediation analysis estimated that ICAM-1 methylation mediated 9% of the association of 28-day PM2.5 with FBG. Conclusions: Among nondiabetics, short- and medium-term PM2.5 were associated with higher FBG. Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation.

Original languageEnglish
Pages (from-to)1715-1721
Number of pages7
JournalEnvironmental Health Perspectives
Volume124
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Air Pollution
Epigenomics
Blood Glucose
Fasting
Intercellular Adhesion Molecule-1
Methylation
Genes
Glucose
Particulate Matter
DNA Methylation
Dementia
Interleukin-6
Cardiovascular Diseases

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Particulate air pollution and fasting blood glucose in nondiabetic individuals : Associations and epigenetic mediation in the normative aging study, 2000-2011. / Peng, Cheng; Bind, Marie Abele C; Colicino, Elena; Kloog, Itai; Byun, Hyang Min; Cantone, Laura; Trevisi, Letizia; Zhong, Jia; Brennan, Kasey; Dereix, Alexandra E.; Vokonas, Pantel S.; Coull, Brent A.; Schwartz, Joel D.; Baccarelli, Andrea A.

In: Environmental Health Perspectives, Vol. 124, No. 11, 01.11.2016, p. 1715-1721.

Research output: Contribution to journalArticle

Peng, C, Bind, MAC, Colicino, E, Kloog, I, Byun, HM, Cantone, L, Trevisi, L, Zhong, J, Brennan, K, Dereix, AE, Vokonas, PS, Coull, BA, Schwartz, JD & Baccarelli, AA 2016, 'Particulate air pollution and fasting blood glucose in nondiabetic individuals: Associations and epigenetic mediation in the normative aging study, 2000-2011', Environmental Health Perspectives, vol. 124, no. 11, pp. 1715-1721. https://doi.org/10.1289/EHP183
Peng, Cheng ; Bind, Marie Abele C ; Colicino, Elena ; Kloog, Itai ; Byun, Hyang Min ; Cantone, Laura ; Trevisi, Letizia ; Zhong, Jia ; Brennan, Kasey ; Dereix, Alexandra E. ; Vokonas, Pantel S. ; Coull, Brent A. ; Schwartz, Joel D. ; Baccarelli, Andrea A. / Particulate air pollution and fasting blood glucose in nondiabetic individuals : Associations and epigenetic mediation in the normative aging study, 2000-2011. In: Environmental Health Perspectives. 2016 ; Vol. 124, No. 11. pp. 1715-1721.
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abstract = "Background: Among nondiabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among nondiabetic individuals. Objectives: Our goals were to investigate whether PM2.5 is associated with an increase in FBG and to explore potential mediating roles of epigenetic gene regulation. Methods: In 551 nondiabetic participants in the Normative Aging Study, we measured FBG, and DNA methylation of four inflammatory genes (IFN-γ, IL-6, ICAM-1, and TLR-2), up to four times between 2000 and 2011 (median = 2). We estimated short- and medium-term (1-, 7-, and 28-day preceding each clinical visit) ambient PM2.5 at each participant’s address using a validated hybrid land-use regression satellite-based model. We fitted covariate-adjusted regression models accounting for repeated measures. Results: Mean FBG was 99.8 mg/dL (SD = 10.7), 18{\%} of the participants had impaired fasting glucose (IFG; i.e., 100–125 mg/dL FBG) at first visit. Interquartile increases in 1-, 7-, and 28-day PM2.5 were associated with 0.57 mg/dL (95{\%} CI: 0.02, 1.11, p = 0.04), 1.02 mg/dL (95{\%} CI: 0.41, 1.63, p = 0.001), and 0.89 mg/dL (95{\%} CI: 0.32, 1.47, p = 0.003) higher FBG, respectively. The same PM2.5 metrics were associated with 13{\%} (95{\%} CI: –3{\%}, 33{\%}, p = 0.12), 27{\%} (95{\%} CI: 6{\%}, 52{\%}, p = 0.01) and 32{\%} (95{\%} CI: 10{\%}, 58{\%}, p = 0.003) higher odds of IFG, respectively. PM2.5 was negatively correlated with ICAM-1 methylation (p = 0.01), but not with other genes. Mediation analysis estimated that ICAM-1 methylation mediated 9{\%} of the association of 28-day PM2.5 with FBG. Conclusions: Among nondiabetics, short- and medium-term PM2.5 were associated with higher FBG. Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation.",
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T1 - Particulate air pollution and fasting blood glucose in nondiabetic individuals

T2 - Associations and epigenetic mediation in the normative aging study, 2000-2011

AU - Peng, Cheng

AU - Bind, Marie Abele C

AU - Colicino, Elena

AU - Kloog, Itai

AU - Byun, Hyang Min

AU - Cantone, Laura

AU - Trevisi, Letizia

AU - Zhong, Jia

AU - Brennan, Kasey

AU - Dereix, Alexandra E.

AU - Vokonas, Pantel S.

AU - Coull, Brent A.

AU - Schwartz, Joel D.

AU - Baccarelli, Andrea A.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: Among nondiabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among nondiabetic individuals. Objectives: Our goals were to investigate whether PM2.5 is associated with an increase in FBG and to explore potential mediating roles of epigenetic gene regulation. Methods: In 551 nondiabetic participants in the Normative Aging Study, we measured FBG, and DNA methylation of four inflammatory genes (IFN-γ, IL-6, ICAM-1, and TLR-2), up to four times between 2000 and 2011 (median = 2). We estimated short- and medium-term (1-, 7-, and 28-day preceding each clinical visit) ambient PM2.5 at each participant’s address using a validated hybrid land-use regression satellite-based model. We fitted covariate-adjusted regression models accounting for repeated measures. Results: Mean FBG was 99.8 mg/dL (SD = 10.7), 18% of the participants had impaired fasting glucose (IFG; i.e., 100–125 mg/dL FBG) at first visit. Interquartile increases in 1-, 7-, and 28-day PM2.5 were associated with 0.57 mg/dL (95% CI: 0.02, 1.11, p = 0.04), 1.02 mg/dL (95% CI: 0.41, 1.63, p = 0.001), and 0.89 mg/dL (95% CI: 0.32, 1.47, p = 0.003) higher FBG, respectively. The same PM2.5 metrics were associated with 13% (95% CI: –3%, 33%, p = 0.12), 27% (95% CI: 6%, 52%, p = 0.01) and 32% (95% CI: 10%, 58%, p = 0.003) higher odds of IFG, respectively. PM2.5 was negatively correlated with ICAM-1 methylation (p = 0.01), but not with other genes. Mediation analysis estimated that ICAM-1 methylation mediated 9% of the association of 28-day PM2.5 with FBG. Conclusions: Among nondiabetics, short- and medium-term PM2.5 were associated with higher FBG. Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation.

AB - Background: Among nondiabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among nondiabetic individuals. Objectives: Our goals were to investigate whether PM2.5 is associated with an increase in FBG and to explore potential mediating roles of epigenetic gene regulation. Methods: In 551 nondiabetic participants in the Normative Aging Study, we measured FBG, and DNA methylation of four inflammatory genes (IFN-γ, IL-6, ICAM-1, and TLR-2), up to four times between 2000 and 2011 (median = 2). We estimated short- and medium-term (1-, 7-, and 28-day preceding each clinical visit) ambient PM2.5 at each participant’s address using a validated hybrid land-use regression satellite-based model. We fitted covariate-adjusted regression models accounting for repeated measures. Results: Mean FBG was 99.8 mg/dL (SD = 10.7), 18% of the participants had impaired fasting glucose (IFG; i.e., 100–125 mg/dL FBG) at first visit. Interquartile increases in 1-, 7-, and 28-day PM2.5 were associated with 0.57 mg/dL (95% CI: 0.02, 1.11, p = 0.04), 1.02 mg/dL (95% CI: 0.41, 1.63, p = 0.001), and 0.89 mg/dL (95% CI: 0.32, 1.47, p = 0.003) higher FBG, respectively. The same PM2.5 metrics were associated with 13% (95% CI: –3%, 33%, p = 0.12), 27% (95% CI: 6%, 52%, p = 0.01) and 32% (95% CI: 10%, 58%, p = 0.003) higher odds of IFG, respectively. PM2.5 was negatively correlated with ICAM-1 methylation (p = 0.01), but not with other genes. Mediation analysis estimated that ICAM-1 methylation mediated 9% of the association of 28-day PM2.5 with FBG. Conclusions: Among nondiabetics, short- and medium-term PM2.5 were associated with higher FBG. Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation.

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