Parvalbumin- and calbindin-containing neurons in the monkey medial geniculate complex: differential distribution and cortical layer specific projections

T. Hashikawa, E. Rausell, M. Molinari, E. G. Jones

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Neuronal immunoreactivity for the calcium binding proteins, parvalbumin and calbindin, has been examined immunohistochemically in the monkey medial geniculate complex. Neurons containing one or other of these proteins were present in most (but not all) regions of the complex and were differentially distributed: parvalbumin immunoreactive neurons tended to form densely packed clusters in the ventral nucleus and rather loose arrangements in the anterodorsal and posterodorsal nuclei, whereas most calbindin neurons were scattered, with concentrations in the caudal end of the posterodorsal and in the magnocellular nuclei. In fluorescent tracer experiments combined with immunohistochemistry, it was found that parvalbumin and calbindin neurons project to layer IV and to layer I, respectively, of the primary auditory cortex. These results suggest the presence of parallel and chemically differentiated geniculocortical pathways which make different contributions to the neuronal circuitry of the auditory cortex.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalBrain Research
Volume544
Issue number2
DOIs
Publication statusPublished - Mar 29 1991

Fingerprint

Geniculate Bodies
Calbindins
Parvalbumins
Haplorhini
Neurons
Auditory Cortex
Anterior Thalamic Nuclei
Calcium-Binding Proteins
Immunohistochemistry
Proteins

Keywords

  • Auditory cortex
  • Calcium binding protein
  • Layer specific projection
  • Thalamic relay cell

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Parvalbumin- and calbindin-containing neurons in the monkey medial geniculate complex : differential distribution and cortical layer specific projections. / Hashikawa, T.; Rausell, E.; Molinari, M.; Jones, E. G.

In: Brain Research, Vol. 544, No. 2, 29.03.1991, p. 335-341.

Research output: Contribution to journalArticle

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