Background: although topical antihistamines were widely prescribed in the past, their current usage is mostly limited to treating sensitive reactions. Materials and methods: 82 consecutive patients with a medical history of adverse drug reactions, of various eczematous lesions or with no drug-induced urticarias were patch tested with eight formulations containing antihistamines, which are sold in Italy. In 8 subjects with eczematous manifestations, tolerability and efficacy against itching in 3 out of the 8 formulations were evaluated. Results: 4 positive patch tests in 2 subjects were recorded, and these were mainly due to commercial formulations containing promethazine (2 cases), maleate dimethindene and chlorhydrate hysotipendile. The 8 subjects with eczematous manifestations reported the 3 products tested to be useful against itching and very tolerable too. Conclusions: although the dermatologic profession has been prescribing these topical therapeutic formulations less than the systemic ones in recent years, owing to their large commercial diffusion and the frequency with which they are self-prescribed, we think that with the exception of some drugs such as promethazine which have been shown to be sensitising, some of the ingredients used should be revaluated for wider use including the dermato-allergologic field.
|Translated title of the contribution||Patch test with commercial products containing antihistamines: Study of 82 patients|
|Number of pages||4|
|Journal||Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale|
|Publication status||Published - Jan 2006|
ASJC Scopus subject areas