Patch urethroplasty using a fascia lata autograft in male rabbits

Fabio Campodonico, A. Michelazzi, E. Ognio, A. Favre, G. Carmignani

Research output: Contribution to journalArticle

Abstract

Introduction: Urethral reconstruction is difficult when the genital skin is not available for surgery. We evaluate the feasibility of using the autologous fascia lata as a graft for urethral repair. Materials and Methods: 10 male rabbits underwent urethroplasty after creation of a ventral urethral defect. The defect was repaired using a graft harvested from the fascia lata. The animals were divided into three groups and sacrificed at 2, 4 and 12 weeks postoperatively. Radiologic control was performed after 10-12 days and before sacrifice. Results: In the 10 rabbits subjected to surgery, no case of death or wound infection was observed. During urethrography, a fistula was observed in 2 animals. In the remainder (n = 8), histological analysis showed the preservation of the original laminar structure without graft shrinkage or fibrosis. On the luminal side of the patch, a new line of urothelium appeared in the 2nd week after surgery. After 3 months, the new epithelium was multilayered and the graft edges were not detectable. No voiding dysfunction was detectable in 8 rabbits. Conclusions: Our study suggests the feasibility of using the autologous fascia lata for urethral patch repair.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalUrologia Internationalis
Volume71
Issue number3
DOIs
Publication statusPublished - 2003

Keywords

  • Fascia lata
  • Hypospadias
  • Rabbit
  • Urethra
  • Urethral stricture
  • Urethroplasty

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Patch urethroplasty using a fascia lata autograft in male rabbits'. Together they form a unique fingerprint.

  • Cite this

    Campodonico, F., Michelazzi, A., Ognio, E., Favre, A., & Carmignani, G. (2003). Patch urethroplasty using a fascia lata autograft in male rabbits. Urologia Internationalis, 71(3), 242-245. https://doi.org/10.1159/000072672