Patents and heart valve surgery - II: Tissue valves

Faisal H. Cheema, Alexander P. Kossar, Atiq Rehman, Fahad Younas, Gianluca Polvani

Research output: Contribution to journalArticlepeer-review


Valvular heart disease affects millions of Americans yearly and currently requires surgical intervention to repair or replace the defective valves. Through a close-knit collaboration between physicians, scientists and biomedical engineers, a vast degree of research and development has been aimed towards the optimization of prosthetic heart valves. Although various methods have made fantastic strides in producing durable prostheses, the therapeutic efficacy of prosthetic valves is inherently limited by a dependency upon lifelong anticoagulant regimens for recipients - a difficult challenge for many in clinical setting. Thus, biological tissue valves have been developed to circumvent vascular and immunemediated complications by incorporating biological materials to mimic native valves while still maintaining a necessary level of structural integrity. Over the past decade, a multitude of patents pertaining to the refinement of designs as well as the advancement in methodologies and technologies associated with biological tissue valves have been issued. This review seeks to chronicle and characterize such patents in an effort to track the past, present, and future progress as well as project the trajectory of tissue valves in the years to come.

Original languageEnglish
Pages (from-to)127-142
Number of pages16
JournalRecent Patents on Cardiovascular Drug Discovery
Issue number2
Publication statusPublished - 2013


  • Bioprosthetic valves
  • Cardiac surgery
  • Patents
  • Tissue heart valve
  • Valvular heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Drug Discovery


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