Pathobiology of anaplastic large cell lymphoma

Pier Paolo Piccaluga, Anna Gazzola, Claudia Mannu, Claudio Agostinelli, Francesco Bacci, Elena Sabattini, Carlo Sagramoso, Roberto Piva, Fernando Roncolato, Giorgio Inghirami, Stefano A. Pileri

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor. The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications. The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms. Finally, the biological rationale for potential innovative targeted therapies is presented.

Original languageEnglish
Article number345053
JournalAdvances in Hematology
Volume2010
DOIs
Publication statusPublished - 2010

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Anaplastic Large-Cell Lymphoma
Investigational Therapies
Lymphoid Tissue
Chromosome Aberrations
Neoplasms
Phenotype
Proteins
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Piccaluga, P. P., Gazzola, A., Mannu, C., Agostinelli, C., Bacci, F., Sabattini, E., ... Pileri, S. A. (2010). Pathobiology of anaplastic large cell lymphoma. Advances in Hematology, 2010, [345053]. https://doi.org/10.1155/2010/345053

Pathobiology of anaplastic large cell lymphoma. / Piccaluga, Pier Paolo; Gazzola, Anna; Mannu, Claudia; Agostinelli, Claudio; Bacci, Francesco; Sabattini, Elena; Sagramoso, Carlo; Piva, Roberto; Roncolato, Fernando; Inghirami, Giorgio; Pileri, Stefano A.

In: Advances in Hematology, Vol. 2010, 345053, 2010.

Research output: Contribution to journalArticle

Piccaluga, PP, Gazzola, A, Mannu, C, Agostinelli, C, Bacci, F, Sabattini, E, Sagramoso, C, Piva, R, Roncolato, F, Inghirami, G & Pileri, SA 2010, 'Pathobiology of anaplastic large cell lymphoma', Advances in Hematology, vol. 2010, 345053. https://doi.org/10.1155/2010/345053
Piccaluga PP, Gazzola A, Mannu C, Agostinelli C, Bacci F, Sabattini E et al. Pathobiology of anaplastic large cell lymphoma. Advances in Hematology. 2010;2010. 345053. https://doi.org/10.1155/2010/345053
Piccaluga, Pier Paolo ; Gazzola, Anna ; Mannu, Claudia ; Agostinelli, Claudio ; Bacci, Francesco ; Sabattini, Elena ; Sagramoso, Carlo ; Piva, Roberto ; Roncolato, Fernando ; Inghirami, Giorgio ; Pileri, Stefano A. / Pathobiology of anaplastic large cell lymphoma. In: Advances in Hematology. 2010 ; Vol. 2010.
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AU - Sagramoso, Carlo

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