Pathobiology of chronic inflammatory skin diseases

Interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Inflammatory dermatoses encompass an enormous area of dermatopathology. These diseases are triggered and maintained by aberrant responses of the cells of the skin immune system. In the last decade it has become clear that epidermal keratinocytes are highly active immunological cells, with a major control over the acute and the chronic phase of skin inflammation by means of cytokine/ chemokine production and surface molecule expression. In their turn, these rather disease-specific events driven by keratinocytes lead to a rich inflammatory infiltrate in the whole skin including the upper layers of the epidermis, and eventually in the aggravation and/or perpetuation of the skin disorder. Recently introduced single molecule-targeted biological drugs are offering the best demonstration that a fine definition of the molecular pathways underlying skin disorders is now necessary to identify the relevant therapeutic targets and finally obtain successful treatment of these diseases. In this review, we will summarize recent progress in our understanding of the immunologic basis of psoriasis, allergic contact dermatitis and atopic dermatitis, with special emphasis on potentially effective targets for novel anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)210-227
Number of pages18
JournalCurrent Drug Metabolism
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Keratinocytes
Skin Diseases
Skin
Anti-Inflammatory Agents
Pharmaceutical Preparations
Dermatitis
Molecules
Allergic Contact Dermatitis
Immune system
Atopic Dermatitis
Chemokines
Psoriasis
Epidermis
Immune System
Demonstrations
Cytokines
Inflammation
Therapeutics

Keywords

  • Allergic contact dermatitis
  • Atopic dermatitis
  • Chemokine
  • Cytokine
  • Dendritic cell
  • Psoriasis
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Pharmacology

Cite this

@article{66bdb8fb7b9d415197ec0728624ba067,
title = "Pathobiology of chronic inflammatory skin diseases: Interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs",
abstract = "Inflammatory dermatoses encompass an enormous area of dermatopathology. These diseases are triggered and maintained by aberrant responses of the cells of the skin immune system. In the last decade it has become clear that epidermal keratinocytes are highly active immunological cells, with a major control over the acute and the chronic phase of skin inflammation by means of cytokine/ chemokine production and surface molecule expression. In their turn, these rather disease-specific events driven by keratinocytes lead to a rich inflammatory infiltrate in the whole skin including the upper layers of the epidermis, and eventually in the aggravation and/or perpetuation of the skin disorder. Recently introduced single molecule-targeted biological drugs are offering the best demonstration that a fine definition of the molecular pathways underlying skin disorders is now necessary to identify the relevant therapeutic targets and finally obtain successful treatment of these diseases. In this review, we will summarize recent progress in our understanding of the immunologic basis of psoriasis, allergic contact dermatitis and atopic dermatitis, with special emphasis on potentially effective targets for novel anti-inflammatory drugs.",
keywords = "Allergic contact dermatitis, Atopic dermatitis, Chemokine, Cytokine, Dendritic cell, Psoriasis, Tumor necrosis factor-α",
author = "C. Albanesi and S. Pastore",
year = "2010",
month = "3",
doi = "10.2174/138920010791196328",
language = "English",
volume = "11",
pages = "210--227",
journal = "Current Drug Metabolism",
issn = "1389-2002",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Pathobiology of chronic inflammatory skin diseases

T2 - Interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs

AU - Albanesi, C.

AU - Pastore, S.

PY - 2010/3

Y1 - 2010/3

N2 - Inflammatory dermatoses encompass an enormous area of dermatopathology. These diseases are triggered and maintained by aberrant responses of the cells of the skin immune system. In the last decade it has become clear that epidermal keratinocytes are highly active immunological cells, with a major control over the acute and the chronic phase of skin inflammation by means of cytokine/ chemokine production and surface molecule expression. In their turn, these rather disease-specific events driven by keratinocytes lead to a rich inflammatory infiltrate in the whole skin including the upper layers of the epidermis, and eventually in the aggravation and/or perpetuation of the skin disorder. Recently introduced single molecule-targeted biological drugs are offering the best demonstration that a fine definition of the molecular pathways underlying skin disorders is now necessary to identify the relevant therapeutic targets and finally obtain successful treatment of these diseases. In this review, we will summarize recent progress in our understanding of the immunologic basis of psoriasis, allergic contact dermatitis and atopic dermatitis, with special emphasis on potentially effective targets for novel anti-inflammatory drugs.

AB - Inflammatory dermatoses encompass an enormous area of dermatopathology. These diseases are triggered and maintained by aberrant responses of the cells of the skin immune system. In the last decade it has become clear that epidermal keratinocytes are highly active immunological cells, with a major control over the acute and the chronic phase of skin inflammation by means of cytokine/ chemokine production and surface molecule expression. In their turn, these rather disease-specific events driven by keratinocytes lead to a rich inflammatory infiltrate in the whole skin including the upper layers of the epidermis, and eventually in the aggravation and/or perpetuation of the skin disorder. Recently introduced single molecule-targeted biological drugs are offering the best demonstration that a fine definition of the molecular pathways underlying skin disorders is now necessary to identify the relevant therapeutic targets and finally obtain successful treatment of these diseases. In this review, we will summarize recent progress in our understanding of the immunologic basis of psoriasis, allergic contact dermatitis and atopic dermatitis, with special emphasis on potentially effective targets for novel anti-inflammatory drugs.

KW - Allergic contact dermatitis

KW - Atopic dermatitis

KW - Chemokine

KW - Cytokine

KW - Dendritic cell

KW - Psoriasis

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=77951703599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951703599&partnerID=8YFLogxK

U2 - 10.2174/138920010791196328

DO - 10.2174/138920010791196328

M3 - Article

VL - 11

SP - 210

EP - 227

JO - Current Drug Metabolism

JF - Current Drug Metabolism

SN - 1389-2002

IS - 3

ER -