Pathobiology of Epstein-Barr virus-driven peripheral T-cell lymphomas

Pier Paolo Piccaluga, Anna Gazzola, Claudio Agostinelli, Francesco Bacci, Elena Sabattini, Stefano A. Pileri

Research output: Contribution to journalArticlepeer-review


In the present review, the authors described the pathobiological features of Epstein-Barr virus (EBV)-driven T/natural killer cell-derived malignancies. These rare tumors appear to be quite heterogeneous with regard to both clinical and pathologic features. Nonetheless, some elements, especially regarding the possible role of EBV (ie, genomic predisposition, pathogenesis, pattern of latency), are similar, enforcing the concept of a causative role for the virus. In clinical practice, although definitely rare in Western countries, the tumors are not exceptional; thus, they should be taken into account in the differential diagnosis of T-lymphoproliferative disorders, also considering the need for extremely prompt intervention. The prognosis of such tumors is generally poor using current approaches. A better understanding of their molecular pathogenesis may lead to significant therapeutic improvements. For example, the nuclear factor-κB pathway and platelet-derived growth factor receptor inhibition may represent 2 options to be tested in clinical trials.

Original languageEnglish
Pages (from-to)234-244
Number of pages11
JournalSeminars in Diagnostic Pathology
Issue number3
Publication statusPublished - Aug 2011


  • EBV
  • Natural killer
  • Peripheral T-cell lymphomas
  • T/NK lymphoproliferative disorder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Pathobiology of Epstein-Barr virus-driven peripheral T-cell lymphomas'. Together they form a unique fingerprint.

Cite this