Pathobiology of Hodgkin lymphoma

Pier Paolo Piccaluga, Claudio Agostinelli, Anna Gazzola, Claudio Tripodo, Francesco Bacci, Elena Sabattini, Maria Teresa Sista, Claudia Mannu, Maria Rosaria Sapienza, Maura Rossi, Maria Antonella Laginestra, Carlo A. Sagramoso-Sacchetti, Simona Righi, Stefano A. Pileri

Research output: Contribution to journalArticlepeer-review


Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied.

Original languageEnglish
Article number920898
JournalAdvances in Hematology
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Hematology


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