TY - JOUR
T1 - Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12
AU - Shafiani, Shahin
AU - Dinh, Crystal
AU - Ertelt, JamesM
AU - Moguche, AlbanusO
AU - Siddiqui, Imran
AU - Smigiel, KateS
AU - Sharma, Pawan
AU - Campbell, DanielJ
AU - Way, SingSing
AU - Urdahl, KevinB
PY - 2013/6/27
Y1 - 2013/6/27
N2 - Thymically derived Foxp3+ regulatory T (Treg) cells have a propensity to recognize self-peptide:MHC complexes, but their ability to respond to epitope-defined foreign antigens during infectious challenge has not been demonstrated. Here we show that pulmonary infection with Mycobacterium tuberculosis (Mtb), but not Listeria monocytogenes (Lm), induced robust lymph node expansion of a highly activated population of pathogen-specific Treg cells from the pre-existing pool of thymically derived Treg cells. These antigen-specific Treg cells peaked in numbers 3weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet. Thus, the initial Mtb-induced inflammatory response promotes pathogen-specific Treg cell proliferation, but these cells are actively culled later, probably to prevent suppression during later stages of infection. These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity.
AB - Thymically derived Foxp3+ regulatory T (Treg) cells have a propensity to recognize self-peptide:MHC complexes, but their ability to respond to epitope-defined foreign antigens during infectious challenge has not been demonstrated. Here we show that pulmonary infection with Mycobacterium tuberculosis (Mtb), but not Listeria monocytogenes (Lm), induced robust lymph node expansion of a highly activated population of pathogen-specific Treg cells from the pre-existing pool of thymically derived Treg cells. These antigen-specific Treg cells peaked in numbers 3weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet. Thus, the initial Mtb-induced inflammatory response promotes pathogen-specific Treg cell proliferation, but these cells are actively culled later, probably to prevent suppression during later stages of infection. These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity.
UR - http://www.scopus.com/inward/record.url?scp=84879604666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879604666&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2013.06.003
DO - 10.1016/j.immuni.2013.06.003
M3 - Article
C2 - 23791647
AN - SCOPUS:84879604666
VL - 38
SP - 1261
EP - 1270
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 6
ER -