Invecchiamento cardiovascolare nel soggetto uremico: nuove acquisizioni.

Translated title of the contribution: Pathogenesis and treatment of vascular calcification in CKD

D. Brancaccio, M. Gallieni, S. Pasho, G. Fallabrino, L. Olivi, E. Volpi, P. Ciceri, E. Missaglia, C. Ronga, C. Brambilla, A. Butti, L. Rocca-Rey, G. Chiarelli, M. Cozzolino

Research output: Contribution to journalArticlepeer-review

Abstract

Increased vascular calcification is a major cause of cardiovascular events in patients with chronic kidney disease (CKD). It is the result of an active ossification process counteracted by ''bone'' proteins such as osteopontin, alkaline phosphatase, osteoprotegerin, and osteocalcin. Chronic kidney disease - mineral and bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism that occurs in CKD. In addition to abnormalities in the serum calcium and phosphate profile, CKD-MBD is characterized by abnormalities of bone turnover, mineralization, volume and growth as well as vascular calcification. Considering that the presence and extent of vascular calcification in CKD portend a poor prognosis, many efforts have been made to shed light on this complicated phenomenon to prevent vascular calcium deposition and its progression. Indeed, careful control of calcium load, serum phosphate and parathyroid hormone along with the use of calcium-free phosphate binders and vitamin D receptor activators represent a new therapeutic armamentarium to improve quality of life and reduce mortality in CKD.

Translated title of the contributionPathogenesis and treatment of vascular calcification in CKD
Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume26 Suppl 45
Publication statusPublished - Mar 2009

ASJC Scopus subject areas

  • Nephrology

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