Il diabete epatogeno

Translated title of the contribution: Pathogenesis of diabetes mellitus in patients with liver cirrhosis: The hepatogenous diabetes

Gianluca Perseghin, Marianna Caloni, Vincenzo Mazzaferro, Livio Luzi

Research output: Contribution to journalArticle


Peripheral insulin-resistance and impairment of the hepatocellular function are two major possible causes of diabetes mellitus in liver cirrhosis. The pathogenesis of insulin-resistance (receptorial or post-receptorial) is unknown but it represents an important complication because it has a profound impact on the pathology and natural history of the liver disease. The ß-cell capacity to compensate the insulin-resistant state to avoid the onset of frank diabetes mellitus plays a critical importance. Many factors may induce a reduction of the ß-cell function in patients with liver cirrhosis: some are due to a predisposition to the development of diabetes: genetic or environmental, unrelated to the hepatic disease; some others are hepatic disease-dependent (excess liver and islet of Langerhans iron deposition, HCV infection rather than other hepatic infections, the co-presence of HCC) and may be crucial because additive to the previous. It is likely that the high prevalence of diabetes in liver cirrhosis is due to the early onset of strong insulin-resistance coupled to a deficient ß-cell function aggravated by hepatic disease-related factors.

Original languageItalian
Pages (from-to)757-761
Number of pages5
JournalRecenti Progressi in Medicina
Issue number12
Publication statusPublished - 2001


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perseghin, G., Caloni, M., Mazzaferro, V., & Luzi, L. (2001). Il diabete epatogeno. Recenti Progressi in Medicina, 92(12), 757-761.