TY - JOUR
T1 - Pathogenesis of Hepatic Encephalopathy and Hyperdynamic Syndrome in Cirrhosis
T2 - Role of False Neurotransmitters
AU - Nespoli, Angelo
AU - Bevilacqua, Giuseppe
AU - Staudacher, Carlo
AU - Rossi, Nicola
AU - Salerno, Francesco
AU - Castelli, Maria Rita
AU - Fischer, Josef E.
PY - 1981
Y1 - 1981
N2 - We sought to determine whether false neurotransmitters (FNTs) play an important role as determinants not only of hepatic encephalopathy but also of hyperdynamic syndrome in cirrhosis. A combined biochemical and hemodynamic study of 55 bleeding cirrhotic patients was made. We evaluated the aromatic and aliphatic branched-chain amino acids and octopamine serum levels as well as the hemodynamic measurements. The results show that there is a correlation between levels of serum octopamine and aromatic amino acids and hepatic coma: the higher the octopamine level, the deeper the hepatic coma. There is also a correlation between aromatic amino acids and cardiac index and total peripheral resistance. Furthermore, when a narrowing of arteriovenous difference in oxygen occurs and oxygen consumption decreases, there is an increase not only in the level of aromatic amino acids, but also in octopamine level, suggesting an important linkage between hemodynamic and metabolic impairment. (Arch Surg 1981;116:1129-1138).
AB - We sought to determine whether false neurotransmitters (FNTs) play an important role as determinants not only of hepatic encephalopathy but also of hyperdynamic syndrome in cirrhosis. A combined biochemical and hemodynamic study of 55 bleeding cirrhotic patients was made. We evaluated the aromatic and aliphatic branched-chain amino acids and octopamine serum levels as well as the hemodynamic measurements. The results show that there is a correlation between levels of serum octopamine and aromatic amino acids and hepatic coma: the higher the octopamine level, the deeper the hepatic coma. There is also a correlation between aromatic amino acids and cardiac index and total peripheral resistance. Furthermore, when a narrowing of arteriovenous difference in oxygen occurs and oxygen consumption decreases, there is an increase not only in the level of aromatic amino acids, but also in octopamine level, suggesting an important linkage between hemodynamic and metabolic impairment. (Arch Surg 1981;116:1129-1138).
UR - http://www.scopus.com/inward/record.url?scp=0019501208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019501208&partnerID=8YFLogxK
U2 - 10.1001/archsurg.1981.01380210013003
DO - 10.1001/archsurg.1981.01380210013003
M3 - Article
C2 - 6793024
AN - SCOPUS:0019501208
VL - 116
SP - 1129
EP - 1138
JO - Archives of Surgery
JF - Archives of Surgery
SN - 0004-0010
IS - 9
ER -