Pathogenesis of liver damage in HCV-HIV patients

Raffaele Bruno, Paolo Sacchi, Massimo Puoti, Laura Maiocchi, S. F A Patruno, Serena Cima, Gaetano Filice

Research output: Contribution to journalArticlepeer-review


The coinfection of HIV and HCV has become a pathology with several distinctive characteristics. Pathogenesis of liver damage in patients with HIV and HCV coinfection is complex and multifactorial. It derives from a balance of factors which interact among themselves in a dynamic way. The reasons for the accelerated course of HIV/HCV coinfection are mainly related to two principal causes: the persistence of HCV, which depends upon alterations of cell-mediated immunity, and the activation of the immune system towards secretion of proinflammatory and profibrotic cytokines. This review will first focus on the characteristics of both these Immune-mediated mechanisms, and then their implication on fibrogenesis as well as on other pathogenetic mechanisms, such as interactions between viruses and the deficit of protective mechanisms. A better knowledge of adaptive immune mechanisms, cytokine alteration, interference with host defense mechanisms, and the "cross-talk" among the viruses will improve the understanding of the pathogenetic mechanism and provide the opportunity to cure this disease.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalAIDS Reviews
Issue number1
Publication statusPublished - Jan 2008


  • HCV coinfection
  • HIV
  • Liver damage
  • Liver fibrosis
  • Pathogenesis

ASJC Scopus subject areas

  • Immunology
  • Virology


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