Pathogenesis of Takayasu's arteritis

Research output: Contribution to journalArticle

Abstract

Takayasu's arteritis is an inflammatory disease of the arteries that involves large vessels. The inflammatory lesions in Takayasu's arteritis originate in the vasa vasorum and are followed by cellular infiltration, mainly composed of T cells (γδ lymphocytes, cytotoxic T lymphocytes, T helper cells), but also of natural killer cells, dendritic cells, monocytes and granulocytes, invading the outer layer of the media and/or its neighbouring adventitia. At this stage, positive production of inflammatory cytokines and/or adhesion molecules around these areas is remarkable. According to data available - in Takayasu's arteritis-interleukin-6, interleukin-1 and RANTES are released in large amounts by infiltrating inflammatory cells within damaged tissue, as well as by circulating inflammatory cells, and very likely help maintain the aberrant immune activation, by promoting endothelial cells activation and by inducing lymphocyte infiltration. Although the nature of the antigen that triggers the auto-immune process is still unknown, the infiltrating T lymphocytes may recognize one or a few self-antigens processed and presented in association with HLA. A considerable percentage of patients with Takayasu's arteritis have immune complexes in sera; moreover, on peripheral blood lymphocyte, Fc receptors and antibodies reactive against human endothelial cells (AECA) have been detected. This observation raised the possibility that AECA might have a role in endothelial cell activation and expression of adhesion molecules, which will facilitate leukocyte traffic.

Original languageEnglish
Pages (from-to)506-513
Number of pages8
JournalJournal of Nephrology
Volume14
Issue number6
Publication statusPublished - 2001

Fingerprint

Takayasu Arteritis
Endothelial Cells
Vasa Vasorum
Lymphocytes
T-Lymphocytes
Chemokine CCL5
Adventitia
Fc Receptors
Autoantigens
Cytotoxic T-Lymphocytes
Lymphocyte Activation
Helper-Inducer T-Lymphocytes
Antigen-Antibody Complex
Interleukin-1
Granulocytes
Natural Killer Cells
Dendritic Cells
Monocytes
Interleukin-6
Leukocytes

Keywords

  • γδ lymphocytes
  • Anti-endothelial cell antibodies
  • Chemokines
  • Cytokines
  • Takayasu's arteritis

ASJC Scopus subject areas

  • Nephrology

Cite this

Pathogenesis of Takayasu's arteritis. / Noris, Marina.

In: Journal of Nephrology, Vol. 14, No. 6, 2001, p. 506-513.

Research output: Contribution to journalArticle

Noris, Marina. / Pathogenesis of Takayasu's arteritis. In: Journal of Nephrology. 2001 ; Vol. 14, No. 6. pp. 506-513.
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