Abstract
Chronic autoimmune or lymphocytic thyroiditis presents with two clinical entities: a goitrous form, referred to as Hashimoto's thyroiditis, and an atrophic form (atrophic thyroiditis or primary myxedema). Hashimoto's thyroiditis, the prototype of autoimmune thyroiditis, is characterized histologically by diffuse lymphocytic infiltration, and clinically by a typical goiter with or without hypothyroidism. Clinical variants include juvenile thyroiditis (lymphocytic thyroiditis of childhood and adolescence) and focal or minimal thyroiditis. In the latter one the degree of lymphocytic infiltration is milder, and there is either no evidence of thyroid dysfunction or subclinical hypothyroidism. A further variant is the form associated with eye changes of Graves' disease. These conditions may represent different stages of a common disorder, or more probably distinct entities with common pathogenetic mechanisms. There is no good evidence that goitrous thyroiditis precedes atrophic thyroiditis, although in hypothyroid patients the degree of fibrosis increases with age. Most cases of silent (painless) thyroiditis and post-partum thyroiditis recognize an autoimmune origin, but their clinical course is typically transient.
| Original language | English |
|---|---|
| Journal | Experimental and Clinical Endocrinology and Diabetes |
| Volume | 107 |
| Issue number | SUPPL. 3 |
| Publication status | Published - 1999 |
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Keywords
- Autoimmune thyroiditis
- Post-partum thyroiditis
- Silent thyroiditis
- Thyroid autoantibodies
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Pathogenetic and clinical aspects of autoimmune thyroiditis. / Marino, Michele; Latrofa, Francesco; Barbesino, Giuseppe; Chiovato, Luca.
In: Experimental and Clinical Endocrinology and Diabetes, Vol. 107, No. SUPPL. 3, 1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogenetic and clinical aspects of autoimmune thyroiditis
AU - Marino, Michele
AU - Latrofa, Francesco
AU - Barbesino, Giuseppe
AU - Chiovato, Luca
PY - 1999
Y1 - 1999
N2 - Chronic autoimmune or lymphocytic thyroiditis presents with two clinical entities: a goitrous form, referred to as Hashimoto's thyroiditis, and an atrophic form (atrophic thyroiditis or primary myxedema). Hashimoto's thyroiditis, the prototype of autoimmune thyroiditis, is characterized histologically by diffuse lymphocytic infiltration, and clinically by a typical goiter with or without hypothyroidism. Clinical variants include juvenile thyroiditis (lymphocytic thyroiditis of childhood and adolescence) and focal or minimal thyroiditis. In the latter one the degree of lymphocytic infiltration is milder, and there is either no evidence of thyroid dysfunction or subclinical hypothyroidism. A further variant is the form associated with eye changes of Graves' disease. These conditions may represent different stages of a common disorder, or more probably distinct entities with common pathogenetic mechanisms. There is no good evidence that goitrous thyroiditis precedes atrophic thyroiditis, although in hypothyroid patients the degree of fibrosis increases with age. Most cases of silent (painless) thyroiditis and post-partum thyroiditis recognize an autoimmune origin, but their clinical course is typically transient.
AB - Chronic autoimmune or lymphocytic thyroiditis presents with two clinical entities: a goitrous form, referred to as Hashimoto's thyroiditis, and an atrophic form (atrophic thyroiditis or primary myxedema). Hashimoto's thyroiditis, the prototype of autoimmune thyroiditis, is characterized histologically by diffuse lymphocytic infiltration, and clinically by a typical goiter with or without hypothyroidism. Clinical variants include juvenile thyroiditis (lymphocytic thyroiditis of childhood and adolescence) and focal or minimal thyroiditis. In the latter one the degree of lymphocytic infiltration is milder, and there is either no evidence of thyroid dysfunction or subclinical hypothyroidism. A further variant is the form associated with eye changes of Graves' disease. These conditions may represent different stages of a common disorder, or more probably distinct entities with common pathogenetic mechanisms. There is no good evidence that goitrous thyroiditis precedes atrophic thyroiditis, although in hypothyroid patients the degree of fibrosis increases with age. Most cases of silent (painless) thyroiditis and post-partum thyroiditis recognize an autoimmune origin, but their clinical course is typically transient.
KW - Autoimmune thyroiditis
KW - Post-partum thyroiditis
KW - Silent thyroiditis
KW - Thyroid autoantibodies
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M3 - Article
VL - 107
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
SN - 0947-7349
IS - SUPPL. 3
ER -