Pathogenetic and prognostic features of lacunar transient ischaemic attack syndromes

Gianluca Landi, Cristina Motto, Ermelinda Cella, Massimo Musicco, Susanna Lipari, Edoardo Boccardi, Mario Guidotti

Research output: Contribution to journalArticlepeer-review


Lacunar ischaemic stroke syndromes are a well defined subgroup of ischaemic strokes. To determine whether a similar subgroup can be identified among patients with transient ischaemic attacks (TIAs) we studied prospectively 102 consecutive patients within 24 hours of their first TIA. Based on their history they were classified as lacunar TIA syndromes (LTIAS; n = 45) if isolated motor or sensory symptoms or their combination had involved at least two of three body parts (face, arm, leg), whereas all other subjects were grouped as non-lacunar TIA syndromes (NLTIAS; n = 57). All patients were investigated according to a standardised protocol and followed up for an average of 51 1 months. Cardiac and arterial sources of thromboembolism were more frequent among NLTIAS (p = 0 0001). Survival curve analysis demonstrated that LTIAS had a significantly lower long term mortality and incidence of major vascular events. In a multivariate regression analysis, the type of TIA (that is, NLTIAS) was an independent predictor of stroke or death. LTIAS share the same distinct pathogenetic and prognostic features of lacunar ischaemic stroke syndromes. These findings have implications for management of TIAs and for studies of their natural history and treatment.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number12
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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