Pathogenetic determinants in Kawasaki disease: the haematological point of view

Research output: Contribution to journalReview article

Abstract

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease. The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than 5%. The etiopathogenesis of this disease remains unclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease. In this review, we summarize the state of the art of pathogenetic mechanisms of Kawasaki disease underscoring the relevance of haematological features as a novel field of investigation.

Original languageEnglish
Pages (from-to)632-639
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

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Mucocutaneous Lymph Node Syndrome
Coronary Vessels
Coronary Stenosis
Intravenous Immunoglobulins
Genetic Predisposition to Disease
Vasculitis
Exanthema
Myocardial Ischemia
Foot
Edema
Fever
Hand
Inflammation
Incidence
Infection

Keywords

  • biomarkers
  • etiopathogenesis
  • genetics
  • haematological features
  • immunity
  • infection
  • Kawasaki disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

Cite this

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title = "Pathogenetic determinants in Kawasaki disease: the haematological point of view",
abstract = "Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease. The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than 5{\%}. The etiopathogenesis of this disease remains unclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease. In this review, we summarize the state of the art of pathogenetic mechanisms of Kawasaki disease underscoring the relevance of haematological features as a novel field of investigation.",
keywords = "biomarkers, etiopathogenesis, genetics, haematological features, immunity, infection, Kawasaki disease",
author = "{Del Principe}, Domenico and Donatella Pietraforte and Lucrezia Gambardella and Alessandra Marchesi and {Tarissi de Jacobis}, Isabella and Alberto Villani and Walter Malorni and Elisabetta Straface",
year = "2017",
month = "4",
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doi = "10.1111/jcmm.12992",
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volume = "21",
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journal = "Journal of Cellular and Molecular Medicine",
issn = "1582-1838",
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TY - JOUR

T1 - Pathogenetic determinants in Kawasaki disease

T2 - the haematological point of view

AU - Del Principe, Domenico

AU - Pietraforte, Donatella

AU - Gambardella, Lucrezia

AU - Marchesi, Alessandra

AU - Tarissi de Jacobis, Isabella

AU - Villani, Alberto

AU - Malorni, Walter

AU - Straface, Elisabetta

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease. The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than 5%. The etiopathogenesis of this disease remains unclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease. In this review, we summarize the state of the art of pathogenetic mechanisms of Kawasaki disease underscoring the relevance of haematological features as a novel field of investigation.

AB - Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease. The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than 5%. The etiopathogenesis of this disease remains unclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease. In this review, we summarize the state of the art of pathogenetic mechanisms of Kawasaki disease underscoring the relevance of haematological features as a novel field of investigation.

KW - biomarkers

KW - etiopathogenesis

KW - genetics

KW - haematological features

KW - immunity

KW - infection

KW - Kawasaki disease

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U2 - 10.1111/jcmm.12992

DO - 10.1111/jcmm.12992

M3 - Review article

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EP - 639

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

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