Pathogenetic determinants in Kawasaki disease: the haematological point of view.

Domenico Del Principe; Donatella Pietraforte; Lucrezia Gambardella; Alessandra Marchesi; Isabella Tarissi De Jacobis; Alberto Villani; Walter Malorni; Elisabetta Straface

Pathogenetic determinants in Kawasaki disease: the haematological point of view.

Domenico Del Principe, Donatella Pietraforte, Lucrezia Gambardella, Alessandra Marchesi, Isabella Tarissi De Jacobis, Alberto Villani, Walter Malorni, Elisabetta Straface

Research output: Contribution to journal › Review article › peer-review

Abstract

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery
lesions. It predominantly affects young children and is characterized by
prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and
feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary
artery involvement is the most important complication of Kawasaki disease and may
cause significant coronary stenosis resulting in ischemic heart disease. The
introduction of intravenous immunoglobulin decreases the incidence of coronary
artery lesions to less than 5%. The etiopathogenesis of this disease remains
unclear. Several lines of evidence suggest that an interplay between a microbial
infection and a genetic predisposition could take place in the development of the
disease. In this review, we summarize the state of the art of pathogenetic
mechanisms of Kawasaki disease underscoring the relevance of haematological
features as a novel field of investigation.

Original language	English
Pages (from-to)	632-639
Number of pages	7
Journal	Journal of Cellular and Molecular Medicine
Volume	21
Publication status	Published - Apr 2017

Keywords

Kawasaki disease

Cite this

@article{0ab408ca9def4926b2615326a807844e,

title = "Pathogenetic determinants in Kawasaki disease: the haematological point of view.",

abstract = "Kawasaki disease is a multisystemic vasculitis that can result in coronary arterylesions. It predominantly affects young children and is characterized byprolonged fever, diffuse mucosal inflammation, indurative oedema of the hands andfeet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronaryartery involvement is the most important complication of Kawasaki disease and maycause significant coronary stenosis resulting in ischemic heart disease. Theintroduction of intravenous immunoglobulin decreases the incidence of coronaryartery lesions to less than 5%. The etiopathogenesis of this disease remainsunclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of thedisease. In this review, we summarize the state of the art of pathogeneticmechanisms of Kawasaki disease underscoring the relevance of haematologicalfeatures as a novel field of investigation.",

keywords = "Kawasaki disease",

author = "{Del Principe}, Domenico and Donatella Pietraforte and Lucrezia Gambardella and Alessandra Marchesi and {Tarissi De Jacobis}, Isabella and Alberto Villani and Walter Malorni and Elisabetta Straface",

year = "2017",

month = apr,

language = "English",

volume = "21",

pages = "632--639",

journal = "Journal of Cellular and Molecular Medicine",

issn = "1582-1838",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Pathogenetic determinants in Kawasaki disease: the haematological point of view.

AU - Del Principe, Domenico

AU - Pietraforte, Donatella

AU - Gambardella, Lucrezia

AU - Marchesi, Alessandra

AU - Tarissi De Jacobis, Isabella

AU - Villani, Alberto

AU - Malorni, Walter

AU - Straface, Elisabetta

PY - 2017/4

Y1 - 2017/4

N2 - Kawasaki disease is a multisystemic vasculitis that can result in coronary arterylesions. It predominantly affects young children and is characterized byprolonged fever, diffuse mucosal inflammation, indurative oedema of the hands andfeet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronaryartery involvement is the most important complication of Kawasaki disease and maycause significant coronary stenosis resulting in ischemic heart disease. Theintroduction of intravenous immunoglobulin decreases the incidence of coronaryartery lesions to less than 5%. The etiopathogenesis of this disease remainsunclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of thedisease. In this review, we summarize the state of the art of pathogeneticmechanisms of Kawasaki disease underscoring the relevance of haematologicalfeatures as a novel field of investigation.

AB - Kawasaki disease is a multisystemic vasculitis that can result in coronary arterylesions. It predominantly affects young children and is characterized byprolonged fever, diffuse mucosal inflammation, indurative oedema of the hands andfeet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronaryartery involvement is the most important complication of Kawasaki disease and maycause significant coronary stenosis resulting in ischemic heart disease. Theintroduction of intravenous immunoglobulin decreases the incidence of coronaryartery lesions to less than 5%. The etiopathogenesis of this disease remainsunclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of thedisease. In this review, we summarize the state of the art of pathogeneticmechanisms of Kawasaki disease underscoring the relevance of haematologicalfeatures as a novel field of investigation.

KW - Kawasaki disease

M3 - Review article

VL - 21

SP - 632

EP - 639

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

ER -

Pathogenetic determinants in Kawasaki disease: the haematological point of view.

Abstract

Keywords

Fingerprint

Cite this