Pathogenic mechanisms mediating antiphospholipid syndrome

Pier Luigi Meroni, Piersandro Riboldi

Research output: Contribution to journalArticle

Abstract

Antiphospholipid antibodies are the marker for antiphospholipid syndrome. There is evidence that these autoantibodies lead to both thrombotic diathesis and obstetrical manifestations. Besides the known interaction with soluble coagulation factors, in vitro and in vivo experimental models and studies in humans recently have shown the ability of antiphospholipid antibodies to modulate functions of cells involved in coagulation homeostasis. These findings support a new hypothesis to explain the paradox of the prolongation of coagulation assays in vitro and the association with thrombophilic diathesis in vivo. Obstetrical manifestations have been linked to a direct antibody effect on the trophoblast leading to defective placentation that is not necessarily associated with thrombotic phenomena. Phospholipid binding proteins such as β2-glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalCurrent Opinion in Rheumatology
Volume13
Issue number5
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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