Pathogenic mechanisms of antiphospholipid syndrome: A new autoimmune disease

Pier Luigi Meroni, Piersandro Riboldi

Research output: Contribution to journalArticle

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the triad of recurrent thrombosis, fetal losses and thrombocytopenia associated with phospholipid binding proteins. The syndrome is a rare example of an autoimmune disease in which the diagnostic autoantibodies are also pathogenic. Owing to the widespread distribution of the target antigens, autoantibodies can interfere with coagulation homeostasis as well as with placentation sustaining the thrombophilia and the miscarriages, respectively. Recent advances in etiology and pathogenesis are changing the knowledge the treatment of the syndrome.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number3
DOIs
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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