Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Irene Alberici, Aysun Karabay Bayazit, Dorota Drozdz, Sevinç Emre, Michel Fischbach, Jérôme Harambat, Augustina Jankauskiene, Mieczyslaw Litwin, Sevgi Mir, William Morello, Amira Peco-Antic, Peter Sallay, Lale Sever, Giacomo D. Simonetti, Przemyslaw Szczesniak, Ana Teixeira, Enrico Vidal, Elke Wuehl, Otto Mehls, Lutz T. WeberFranz Schaefer, Giovanni Montini

Research output: Contribution to journalArticle

Abstract

Knowledge of the distribution spectrum of causative organisms and their resistance patterns has become a core requirement for the rational and effective management of urinary tract infections. In the context of a prospective trial on the use of antibiotic prophylaxis in infants with underling kidney malformations, we conducted an online survey among paediatric nephrologists on positive urine cultures (July 2010–June 2012) from both hospitalized and non-hospitalized infants under 24 months of age. We collected 4745 urine cultures (UCs) at 18 units in 10 European countries. Escherichia coli was the most frequent bacterium isolated from UCs; however, in 10/16 hospitals and in 6/15 community settings, E. coli was isolated in less than 50 % of the total positive UCs. Other bacterial strains were Klebsiella, Enterococcus, Proteus and Pseudomonas not only from hospital settings. E. coli showed a high resistance to amoxicillin and trimethoprim and variable to cephalosporin. Nitrofurantoin had a good rate of efficacy, with 11/16 hospitals and 11/14 community settings reporting a resistance lower than 5 %. Conclusion: E. coli is the most common organism causing UTIs in infants; however, other bacterial strains are frequently isolated. As a result, antibiotic prophylaxis should be more elastic and adaptable over time in order to guarantee maximum efficacy.

Original languageEnglish
Pages (from-to)783-790
Number of pages8
JournalEuropean Journal of Pediatrics
Volume174
Issue number6
DOIs
Publication statusPublished - Nov 28 2015

Fingerprint

Urinary Tract Infections
Urine
Escherichia coli
Antibiotic Prophylaxis
Nitrofurantoin
Proteus
Trimethoprim
Klebsiella
Amoxicillin
Enterococcus
Cephalosporins
Pseudomonas
Pediatrics
Bacteria
Kidney

Keywords

  • Antibiotic resistance
  • Escherichia coli
  • Infants
  • Urinary tract infection
  • Urine culture

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pathogens causing urinary tract infections in infants : a European overview by the ESCAPE study group. / Alberici, Irene; Bayazit, Aysun Karabay; Drozdz, Dorota; Emre, Sevinç; Fischbach, Michel; Harambat, Jérôme; Jankauskiene, Augustina; Litwin, Mieczyslaw; Mir, Sevgi; Morello, William; Peco-Antic, Amira; Sallay, Peter; Sever, Lale; Simonetti, Giacomo D.; Szczesniak, Przemyslaw; Teixeira, Ana; Vidal, Enrico; Wuehl, Elke; Mehls, Otto; Weber, Lutz T.; Schaefer, Franz; Montini, Giovanni.

In: European Journal of Pediatrics, Vol. 174, No. 6, 28.11.2015, p. 783-790.

Research output: Contribution to journalArticle

Alberici, I, Bayazit, AK, Drozdz, D, Emre, S, Fischbach, M, Harambat, J, Jankauskiene, A, Litwin, M, Mir, S, Morello, W, Peco-Antic, A, Sallay, P, Sever, L, Simonetti, GD, Szczesniak, P, Teixeira, A, Vidal, E, Wuehl, E, Mehls, O, Weber, LT, Schaefer, F & Montini, G 2015, 'Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group', European Journal of Pediatrics, vol. 174, no. 6, pp. 783-790. https://doi.org/10.1007/s00431-014-2459-3
Alberici, Irene ; Bayazit, Aysun Karabay ; Drozdz, Dorota ; Emre, Sevinç ; Fischbach, Michel ; Harambat, Jérôme ; Jankauskiene, Augustina ; Litwin, Mieczyslaw ; Mir, Sevgi ; Morello, William ; Peco-Antic, Amira ; Sallay, Peter ; Sever, Lale ; Simonetti, Giacomo D. ; Szczesniak, Przemyslaw ; Teixeira, Ana ; Vidal, Enrico ; Wuehl, Elke ; Mehls, Otto ; Weber, Lutz T. ; Schaefer, Franz ; Montini, Giovanni. / Pathogens causing urinary tract infections in infants : a European overview by the ESCAPE study group. In: European Journal of Pediatrics. 2015 ; Vol. 174, No. 6. pp. 783-790.
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