Pathologic examination of the axillary sentinel lymph nodes in patients with early-stage breast carcinoma: Current and resolving controversies on the basis of the European Institute of Oncology experience

Giuseppe Viale, Mauro G. Mastropasqua, Eugenio Maiorano, Giovanni Mazzarol

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Several controversial aspects of sentinel lymph node biopsy (SLNB) for patients with early-stage, node-negative breast carcinoma have been dealt with and resolved in the past decade since its introduction. Unfortunately, however, there is still no consensus on how best to examine sentinel lymph nodes (SLN) histologically. As a consequence, the protocols for SLN examination are remarkably variable in different institutions, leading to a very poor reproducibility of the data stemming from investigations on series of patients whose SLNs have been evaluated according to diverse protocols. Patient outcomes, however, can be optimised only by standardization of the whole procedure of SLNB, with particular reference to the histopathologic scrutiny. Lack of a standardized histopathologic protocol likely derives also from the uncertainties about the clinical implications of minimal lymph node involvement (isolated tumour cells and micrometastases) with regard both to the risk of additional metastases to non-sentinel lymph nodes of the same basin and to the prognostic value for patients' survival. This review aims at highlighting some of the controversial issues of the histopathologic examination of the SLNs, including the number of sections and cutting intervals, the use of immunohistochemistry and the role of molecular biology assays.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalVirchows Archiv
Volume448
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Breast Neoplasms
Sentinel Lymph Node Biopsy
Lymph Nodes
Neoplasm Micrometastasis
Uncertainty
Molecular Biology
Immunohistochemistry
Neoplasm Metastasis
Survival
Sentinel Lymph Node
Neoplasms

Keywords

  • Breast carcinoma
  • Micrometastasis
  • Sentinel node biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{a879985e665d4a3b848adcd150414193,
title = "Pathologic examination of the axillary sentinel lymph nodes in patients with early-stage breast carcinoma: Current and resolving controversies on the basis of the European Institute of Oncology experience",
abstract = "Several controversial aspects of sentinel lymph node biopsy (SLNB) for patients with early-stage, node-negative breast carcinoma have been dealt with and resolved in the past decade since its introduction. Unfortunately, however, there is still no consensus on how best to examine sentinel lymph nodes (SLN) histologically. As a consequence, the protocols for SLN examination are remarkably variable in different institutions, leading to a very poor reproducibility of the data stemming from investigations on series of patients whose SLNs have been evaluated according to diverse protocols. Patient outcomes, however, can be optimised only by standardization of the whole procedure of SLNB, with particular reference to the histopathologic scrutiny. Lack of a standardized histopathologic protocol likely derives also from the uncertainties about the clinical implications of minimal lymph node involvement (isolated tumour cells and micrometastases) with regard both to the risk of additional metastases to non-sentinel lymph nodes of the same basin and to the prognostic value for patients' survival. This review aims at highlighting some of the controversial issues of the histopathologic examination of the SLNs, including the number of sections and cutting intervals, the use of immunohistochemistry and the role of molecular biology assays.",
keywords = "Breast carcinoma, Micrometastasis, Sentinel node biopsy",
author = "Giuseppe Viale and Mastropasqua, {Mauro G.} and Eugenio Maiorano and Giovanni Mazzarol",
year = "2006",
month = "3",
doi = "10.1007/s00428-005-0103-3",
language = "English",
volume = "448",
pages = "241--247",
journal = "Virchows Archiv - A Pathological Anatomy and Histopathology",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Pathologic examination of the axillary sentinel lymph nodes in patients with early-stage breast carcinoma

T2 - Current and resolving controversies on the basis of the European Institute of Oncology experience

AU - Viale, Giuseppe

AU - Mastropasqua, Mauro G.

AU - Maiorano, Eugenio

AU - Mazzarol, Giovanni

PY - 2006/3

Y1 - 2006/3

N2 - Several controversial aspects of sentinel lymph node biopsy (SLNB) for patients with early-stage, node-negative breast carcinoma have been dealt with and resolved in the past decade since its introduction. Unfortunately, however, there is still no consensus on how best to examine sentinel lymph nodes (SLN) histologically. As a consequence, the protocols for SLN examination are remarkably variable in different institutions, leading to a very poor reproducibility of the data stemming from investigations on series of patients whose SLNs have been evaluated according to diverse protocols. Patient outcomes, however, can be optimised only by standardization of the whole procedure of SLNB, with particular reference to the histopathologic scrutiny. Lack of a standardized histopathologic protocol likely derives also from the uncertainties about the clinical implications of minimal lymph node involvement (isolated tumour cells and micrometastases) with regard both to the risk of additional metastases to non-sentinel lymph nodes of the same basin and to the prognostic value for patients' survival. This review aims at highlighting some of the controversial issues of the histopathologic examination of the SLNs, including the number of sections and cutting intervals, the use of immunohistochemistry and the role of molecular biology assays.

AB - Several controversial aspects of sentinel lymph node biopsy (SLNB) for patients with early-stage, node-negative breast carcinoma have been dealt with and resolved in the past decade since its introduction. Unfortunately, however, there is still no consensus on how best to examine sentinel lymph nodes (SLN) histologically. As a consequence, the protocols for SLN examination are remarkably variable in different institutions, leading to a very poor reproducibility of the data stemming from investigations on series of patients whose SLNs have been evaluated according to diverse protocols. Patient outcomes, however, can be optimised only by standardization of the whole procedure of SLNB, with particular reference to the histopathologic scrutiny. Lack of a standardized histopathologic protocol likely derives also from the uncertainties about the clinical implications of minimal lymph node involvement (isolated tumour cells and micrometastases) with regard both to the risk of additional metastases to non-sentinel lymph nodes of the same basin and to the prognostic value for patients' survival. This review aims at highlighting some of the controversial issues of the histopathologic examination of the SLNs, including the number of sections and cutting intervals, the use of immunohistochemistry and the role of molecular biology assays.

KW - Breast carcinoma

KW - Micrometastasis

KW - Sentinel node biopsy

UR - http://www.scopus.com/inward/record.url?scp=33644830410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644830410&partnerID=8YFLogxK

U2 - 10.1007/s00428-005-0103-3

DO - 10.1007/s00428-005-0103-3

M3 - Article

C2 - 16362823

AN - SCOPUS:33644830410

VL - 448

SP - 241

EP - 247

JO - Virchows Archiv - A Pathological Anatomy and Histopathology

JF - Virchows Archiv - A Pathological Anatomy and Histopathology

SN - 0945-6317

IS - 3

ER -