Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: Relevance to prognosis and tumor staging

Giacomo Puppa, Patrick Maisonneuve, Angelica Sonzogni, Michele Masullo, Paola Capelli, Marco Chilosi, Fabio Menestrina, Giuseppe Viale, Giuseppe Pelosi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The current TNM classification considers a tumor nodule in the pericolic/perirectal adipose tissue as venous invasion if the nodule has an irregular contour and as regional lymph node metastasis if the nodule has the form and smooth contour of a lymph node. However, detailed studies on the clinico-pathological implications of pericolonic tumor deposits and of extranodal extension are still lacking. We investigated the impact of these metastatic deposits in the pericolic fat in a series of 228 patients with advanced colon cancer. The pericolonic tumor deposits were characterized by their appearance, size, distance from the primary tumor and by their relation with the lymphatic tissue not organized in lymph nodes. These features were then compared with the clinico-pathological characteristics of the tumors and with the patients' survival. All these lesions were associated with reduced disease-free and overall survivals in a univariate analysis, but only pericolonic tumor deposits retained an independent prognostic role in the multivariate analysis. Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes.

Original languageEnglish
Pages (from-to)843-855
Number of pages13
JournalModern Pathology
Volume20
Issue number8
DOIs
Publication statusPublished - Aug 11 2007

Fingerprint

Neoplasm Staging
Carcinoma
Neoplasms
Lymph Nodes
Lymphoid Tissue
Colonic Neoplasms
Disease-Free Survival
Adipose Tissue
Multivariate Analysis
Fats
Neoplasm Metastasis
Survival

Keywords

  • Colonic carcinoma
  • Extracapsular tumor spread
  • Lymphatic invasion
  • Pericolonic tumor deposits
  • Prognosis
  • Vascular invasion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma : Relevance to prognosis and tumor staging. / Puppa, Giacomo; Maisonneuve, Patrick; Sonzogni, Angelica; Masullo, Michele; Capelli, Paola; Chilosi, Marco; Menestrina, Fabio; Viale, Giuseppe; Pelosi, Giuseppe.

In: Modern Pathology, Vol. 20, No. 8, 11.08.2007, p. 843-855.

Research output: Contribution to journalArticle

@article{9c17cb61f2f147bf9322d95b150d0323,
title = "Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: Relevance to prognosis and tumor staging",
abstract = "The current TNM classification considers a tumor nodule in the pericolic/perirectal adipose tissue as venous invasion if the nodule has an irregular contour and as regional lymph node metastasis if the nodule has the form and smooth contour of a lymph node. However, detailed studies on the clinico-pathological implications of pericolonic tumor deposits and of extranodal extension are still lacking. We investigated the impact of these metastatic deposits in the pericolic fat in a series of 228 patients with advanced colon cancer. The pericolonic tumor deposits were characterized by their appearance, size, distance from the primary tumor and by their relation with the lymphatic tissue not organized in lymph nodes. These features were then compared with the clinico-pathological characteristics of the tumors and with the patients' survival. All these lesions were associated with reduced disease-free and overall survivals in a univariate analysis, but only pericolonic tumor deposits retained an independent prognostic role in the multivariate analysis. Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes.",
keywords = "Colonic carcinoma, Extracapsular tumor spread, Lymphatic invasion, Pericolonic tumor deposits, Prognosis, Vascular invasion",
author = "Giacomo Puppa and Patrick Maisonneuve and Angelica Sonzogni and Michele Masullo and Paola Capelli and Marco Chilosi and Fabio Menestrina and Giuseppe Viale and Giuseppe Pelosi",
year = "2007",
month = "8",
day = "11",
doi = "10.1038/modpathol.3800791",
language = "English",
volume = "20",
pages = "843--855",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma

T2 - Relevance to prognosis and tumor staging

AU - Puppa, Giacomo

AU - Maisonneuve, Patrick

AU - Sonzogni, Angelica

AU - Masullo, Michele

AU - Capelli, Paola

AU - Chilosi, Marco

AU - Menestrina, Fabio

AU - Viale, Giuseppe

AU - Pelosi, Giuseppe

PY - 2007/8/11

Y1 - 2007/8/11

N2 - The current TNM classification considers a tumor nodule in the pericolic/perirectal adipose tissue as venous invasion if the nodule has an irregular contour and as regional lymph node metastasis if the nodule has the form and smooth contour of a lymph node. However, detailed studies on the clinico-pathological implications of pericolonic tumor deposits and of extranodal extension are still lacking. We investigated the impact of these metastatic deposits in the pericolic fat in a series of 228 patients with advanced colon cancer. The pericolonic tumor deposits were characterized by their appearance, size, distance from the primary tumor and by their relation with the lymphatic tissue not organized in lymph nodes. These features were then compared with the clinico-pathological characteristics of the tumors and with the patients' survival. All these lesions were associated with reduced disease-free and overall survivals in a univariate analysis, but only pericolonic tumor deposits retained an independent prognostic role in the multivariate analysis. Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes.

AB - The current TNM classification considers a tumor nodule in the pericolic/perirectal adipose tissue as venous invasion if the nodule has an irregular contour and as regional lymph node metastasis if the nodule has the form and smooth contour of a lymph node. However, detailed studies on the clinico-pathological implications of pericolonic tumor deposits and of extranodal extension are still lacking. We investigated the impact of these metastatic deposits in the pericolic fat in a series of 228 patients with advanced colon cancer. The pericolonic tumor deposits were characterized by their appearance, size, distance from the primary tumor and by their relation with the lymphatic tissue not organized in lymph nodes. These features were then compared with the clinico-pathological characteristics of the tumors and with the patients' survival. All these lesions were associated with reduced disease-free and overall survivals in a univariate analysis, but only pericolonic tumor deposits retained an independent prognostic role in the multivariate analysis. Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes.

KW - Colonic carcinoma

KW - Extracapsular tumor spread

KW - Lymphatic invasion

KW - Pericolonic tumor deposits

KW - Prognosis

KW - Vascular invasion

UR - http://www.scopus.com/inward/record.url?scp=34447580035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447580035&partnerID=8YFLogxK

U2 - 10.1038/modpathol.3800791

DO - 10.1038/modpathol.3800791

M3 - Article

C2 - 17491597

AN - SCOPUS:34447580035

VL - 20

SP - 843

EP - 855

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 8

ER -