Pathological definitions of invasion, metastatic potential and responsiveness to targeted therapies

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The tailored treatment of patients with primary breast carcinoma relies mainly on the assessment of invasion, metastatic potential and responsiveness to targeted therapies. Accordingly, the role of the pathologist is to ensure the most accurate evaluation of the prognostic and predictive parameters, which will have a major impact in the planning of the adjuvant interventions. Every effort has to be made to improve the accuracy and the inter-laboratory reproducibility of the histopathological and biological characterization of breast carcinomas, taking advantage of the newly developed molecular assays. This review article will focus mainly on some controversial issues, like intracystic papillary carcinomas, whose invasive or non-invasive nature is still debated; the suitability of sophisticated molecular assays to assess the metastatic potential of primary breast carcinomas better than what is currently done; and the need for modifying the scoring criteria of the assays to assess tumor responsiveness to anti-HER2 treatments.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalBreast
Volume16
Issue number2 SUPPL.
DOIs
Publication statusPublished - 2007

Fingerprint

Breast Neoplasms
Papillary Carcinoma
Therapeutics
Neoplasms
Pathologists

Keywords

  • Her2 over-expression
  • Hormone receptor status
  • Intracystic papillary carcinoma
  • Metastases

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Pathological definitions of invasion, metastatic potential and responsiveness to targeted therapies. / Viale, Giuseppe.

In: Breast, Vol. 16, No. 2 SUPPL., 2007, p. 55-58.

Research output: Contribution to journalArticle

@article{8021da728c4d40438d1a5cf8b46bc3ee,
title = "Pathological definitions of invasion, metastatic potential and responsiveness to targeted therapies",
abstract = "The tailored treatment of patients with primary breast carcinoma relies mainly on the assessment of invasion, metastatic potential and responsiveness to targeted therapies. Accordingly, the role of the pathologist is to ensure the most accurate evaluation of the prognostic and predictive parameters, which will have a major impact in the planning of the adjuvant interventions. Every effort has to be made to improve the accuracy and the inter-laboratory reproducibility of the histopathological and biological characterization of breast carcinomas, taking advantage of the newly developed molecular assays. This review article will focus mainly on some controversial issues, like intracystic papillary carcinomas, whose invasive or non-invasive nature is still debated; the suitability of sophisticated molecular assays to assess the metastatic potential of primary breast carcinomas better than what is currently done; and the need for modifying the scoring criteria of the assays to assess tumor responsiveness to anti-HER2 treatments.",
keywords = "Her2 over-expression, Hormone receptor status, Intracystic papillary carcinoma, Metastases",
author = "Giuseppe Viale",
year = "2007",
doi = "10.1016/j.breast.2007.07.007",
language = "English",
volume = "16",
pages = "55--58",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "2 SUPPL.",

}

TY - JOUR

T1 - Pathological definitions of invasion, metastatic potential and responsiveness to targeted therapies

AU - Viale, Giuseppe

PY - 2007

Y1 - 2007

N2 - The tailored treatment of patients with primary breast carcinoma relies mainly on the assessment of invasion, metastatic potential and responsiveness to targeted therapies. Accordingly, the role of the pathologist is to ensure the most accurate evaluation of the prognostic and predictive parameters, which will have a major impact in the planning of the adjuvant interventions. Every effort has to be made to improve the accuracy and the inter-laboratory reproducibility of the histopathological and biological characterization of breast carcinomas, taking advantage of the newly developed molecular assays. This review article will focus mainly on some controversial issues, like intracystic papillary carcinomas, whose invasive or non-invasive nature is still debated; the suitability of sophisticated molecular assays to assess the metastatic potential of primary breast carcinomas better than what is currently done; and the need for modifying the scoring criteria of the assays to assess tumor responsiveness to anti-HER2 treatments.

AB - The tailored treatment of patients with primary breast carcinoma relies mainly on the assessment of invasion, metastatic potential and responsiveness to targeted therapies. Accordingly, the role of the pathologist is to ensure the most accurate evaluation of the prognostic and predictive parameters, which will have a major impact in the planning of the adjuvant interventions. Every effort has to be made to improve the accuracy and the inter-laboratory reproducibility of the histopathological and biological characterization of breast carcinomas, taking advantage of the newly developed molecular assays. This review article will focus mainly on some controversial issues, like intracystic papillary carcinomas, whose invasive or non-invasive nature is still debated; the suitability of sophisticated molecular assays to assess the metastatic potential of primary breast carcinomas better than what is currently done; and the need for modifying the scoring criteria of the assays to assess tumor responsiveness to anti-HER2 treatments.

KW - Her2 over-expression

KW - Hormone receptor status

KW - Intracystic papillary carcinoma

KW - Metastases

UR - http://www.scopus.com/inward/record.url?scp=35648993429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35648993429&partnerID=8YFLogxK

U2 - 10.1016/j.breast.2007.07.007

DO - 10.1016/j.breast.2007.07.007

M3 - Article

C2 - 17714946

AN - SCOPUS:35648993429

VL - 16

SP - 55

EP - 58

JO - Breast

JF - Breast

SN - 0960-9776

IS - 2 SUPPL.

ER -