Pathological relevance of the natural immune system

Stefano Salvioli, Miriam Capri, Cristiana Fumelli, Francesco Lescai, Daniela Monti, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review


The natural immune response is a pre-programmed, non specific first line of defence that is primarily responsible for eliminating or containing pathogenes at the site of entrance into the host. This evolutionary conserved function was primarily described in cells of the immune system, but it is now known to exist in various tissues, where its activation plays a significant role in host defence, autoimmunity, inflammatory disease and pathogenesis of sepsis-induced multiorgan dysfunction. It is also emerging in the last years as a possible role for natural immunity in the aging process, and its role in tumour immunosurveillance is undergoing a great revival. This Chapter will briefly summarise the importance of natural immunity in all of these phenomena.

Original languageEnglish
Pages (from-to)331-350
Number of pages20
JournalNeuroImmune Biology
Issue numberC
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Neurology


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