Endometrial adenocarcinoma is a complex disease whose morphologic heterogeneity, with its biologic and clinical implications, has been well shown by Bokhman's dualistic model until recent years. The classification of endometrial carcinomas in two broad categories, morphologically distinguishable and based on different molecular events during oncogenesis, had relevant clinical consequences identifying groups of tumors with different clinical behavior. In this chapter, we will examine the main histologic variants of endometrial carcinoma, according to World Health Organization (WHO) classification and to Bokhman's dualistic model, focusing on their prognostic value. Other prognostic factors will be considered in order to underline the pathologist's role in taking therapeutic decisions. However, recently Bokhman's model has been questioned, because of the low diagnostic agreement on high grade and mixed carcinomas among expert gynecologic pathologists, because of the identification of ambiguous carcinomas with uninformative morphologic features and because of the presence of a certain grade of overlapping altered molecular pathways in tumors belonging to different categories.
|Title of host publication||Endometrial Cancer: Prevention, Diagnosis and Treatment|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||24|
|Publication status||Published - Feb 2013|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)