Pathology of hepatocellular carcinoma

Francesco Callea, Maurizio Favret, Carla Marino, Massimo Brisigotti

Research output: Contribution to journalArticle


This study provides a guideline to a dynamic approach toward the diagnosis of hepatocellular carcinoma (HCC). Bile production, fibrinogen synthesis, Mallory body, fibrinogen ground‐glass and abnormal glycogen bodies as a reflection of “clone” selection, and hepatitis B virus (HBV) antigen expression in tumer cells can be considered as markers for the morphological diagnosis of HCC. The demonstration in tumor cells of these diagnostic features requires a careful screening of routinely stained preparations in search of suggestive, characteristic, specific, or pathognomonic features further supplemented by ancillary techniques, such as histochemistry, immunocytochemistry, and electron microscopy. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)168-169
Number of pages2
JournalJournal of Surgical Oncology
Issue number3 S
Publication statusPublished - 1993



  • hepatocellular carcinoma
  • immunohistoehemistry
  • pathology

ASJC Scopus subject areas

  • Surgery
  • Oncology

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