Pathomechanisms: Homeostatic chemokines in health, tissue regeneration, and progressive diseases

Hans Joachim Anders, Paola Romagnani, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Homeostatic chemokines control stem and progenitor cell migration and activation during vasculogenesis and organ development. They orchestrate hematopoietic stem cell (HSC) homing to their bone marrow niches and direct immature lymphocytes to a series of maturation sites within lymphoid organs. Along these lines, homeostatic chemokines regulate the niches of peripheral committed progenitor cell populations for tissue renewal. These biological functions support neovascularization and wound healing, including the recruitment of endothelial and other progenitor cells from the bone marrow. Here, we summarize the roles of homeostatic chemokines, their signaling receptors, and atypical decoy receptors during homeostasis and tissue regeneration in order to better understand their pathogenic roles in disease, for example, in diabetes complications, cancer, autoimmunity, epithelial hyperplasia, or hypertrophic scarring and fibrosis.

Original languageEnglish
Pages (from-to)154-165
Number of pages12
JournalTrends in Molecular Medicine
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Chemokine receptor
  • Inflammation
  • Malignancy
  • Regeneration
  • Tissue damage

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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