Pathophysiological Characteristics of Long- and Short-Segment Barrett's Oesophagus

P. Zentilin, S. Reglioni, V. Savarino

Research output: Contribution to journalArticlepeer-review


Background: Depending on the length of the segment of columnar epithelium in the distal oesophagus, Barrett's oesophagus can be divided into long-segment and short-segment Barrett's oesophagus. This article describes the pathophysiological characteristics of both forms of Barrett's oesophagus. Methods: Review of the literature. Results: Although there is some disagreement, ours and most other studies suggest that long-segment columnar-lined oesophagus is causally linked to chronic gastro-oesophageal reflux and that this from of Barrett's oesophagus is characterized by lower oesophageal sphincter tone, reduced oesophageal contractility and increased acid reflux. Short-segment Barrett's oesophagus is also associated with acid reflux, but the degree of oesophageal acid exposure and the level of other pathophysiological alterations seem to be lower. Conclusion: Pathophysiological abnormalities appear to be more prominent in long-segment Barrett's oesophagus than in short-segment Barrett's oesophagus.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalScandinavian Journal of Gastroenterology, Supplement
Issue number239
Publication statusPublished - 2003


  • Barrett's oesophagus
  • Oesophageal manometry
  • Oesophageal pH-monitoring

ASJC Scopus subject areas

  • Gastroenterology


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