TY - JOUR
T1 - Pathophysiological role and therapeutic implications of vitamin d in autoimmunity
T2 - Focus on chronic autoimmune diseases
AU - Bellan, Mattia
AU - Andreoli, Laura
AU - Mele, Chiara
AU - Sainaghi, Pier Paolo
AU - Rigamonti, Cristina
AU - Piantoni, Silvia
AU - Benedittis, Carla De
AU - Aimaretti, Gianluca
AU - Pirisi, Mario
AU - Marzullo, Paolo
N1 - Funding Information:
Funding: This study was partly funded by the AGING Project for Department of Excellence at the Department of Translational Medicine (DIMET), Università del Piemonte Orientale, Novara, Italy.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - Vitamin D is a pleiotropic secosteroid yielding multiple actions in human physiology. Besides the canonical regulatory activity on bone metabolism, several non-classical actions have been described and the ability of vitamin D to partake in the regulation of the immune system is particularly interesting, though far stronger and convincing evidence has been collected in in vitro as compared to in vivo studies. Whether vitamin D is able to regulate at physiological concentrations the human immune system remains unproven to date. Consequently, it is not established if vitamin D status is a factor involved in the pathogenesis of immune-mediated diseases and if cholecalciferol supplementation acts as an adjuvant for autoimmune diseases. The development of autoimmunity is a heterogeneous process, which may involve different organs and systems with a wide range of clinical implications. In the present paper, we reviewed the current evidences regarding vitamin D role in the pathogenesis and management of different autoimmune diseases.
AB - Vitamin D is a pleiotropic secosteroid yielding multiple actions in human physiology. Besides the canonical regulatory activity on bone metabolism, several non-classical actions have been described and the ability of vitamin D to partake in the regulation of the immune system is particularly interesting, though far stronger and convincing evidence has been collected in in vitro as compared to in vivo studies. Whether vitamin D is able to regulate at physiological concentrations the human immune system remains unproven to date. Consequently, it is not established if vitamin D status is a factor involved in the pathogenesis of immune-mediated diseases and if cholecalciferol supplementation acts as an adjuvant for autoimmune diseases. The development of autoimmunity is a heterogeneous process, which may involve different organs and systems with a wide range of clinical implications. In the present paper, we reviewed the current evidences regarding vitamin D role in the pathogenesis and management of different autoimmune diseases.
KW - Addison’s disease
KW - Antiphospholipid syndrome
KW - Autoimmune diseases
KW - Autoimmune liver disease
KW - Autoimmune thyroid disease
KW - Autoimmunity
KW - Rheumatoid arthritis
KW - Spondyloarthritis
KW - Systemic lupus erythematosus
KW - Type 1 diabetes mellitus
KW - Vitamin D
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U2 - 10.3390/nu12030789
DO - 10.3390/nu12030789
M3 - Review article
C2 - 32192175
AN - SCOPUS:85081997261
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 789
ER -