Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury

Marisol Mirabelli-Badenier, Vincent Braunersreuther, Sébastien Lenglet, Katia Galan, Edvige Veneselli, Giorgio L. Viviani, François Mach, Fabrizio Montecucco

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ischaemic stroke is one of the major causes of death and lifelong disability also in the paediatric population. Strong scientific effort has been put to clarify the pathophysiology of this disease in adults. However, only few studies have been performed in children. Preliminary results indicate that pathophysiological processes might differently affect the poststroke neuronal injury in neonates as compared to children. During the neural development, selective molecular mechanisms might be differently triggered by an ischaemic insult, thus potentially resulting in defined postischaemic clinical outcomes. Basic research studies in neonatal animal models of cerebral ischaemia have recently shown a potential role of soluble inflammatory molecules (such as cytokines, chemokines and oxidants) as pivotal players of neuronal injury in both perinatal and childhood ischaemic stroke. Although larger clinical trials are still needed to confirm these preliminary results, the potential benefits of selective treatments targeting inflammation in perinatal asphyxia encephalopathy might represent a promising investigation field in the near future. In this review, we will update evidence on the pathophysiological role of soluble inflammatory mediators in neonatal and childhood ischaemic stroke. Recent evidence on potential anti-inflammatory treatments to improve paediatric stroke prognosis will be discussed.

Original languageEnglish
Pages (from-to)784-794
Number of pages11
JournalEuropean Journal of Clinical Investigation
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Pediatrics
Brain Injuries
Brain
Stroke
Molecules
Chemokines
Oxidants
Animals
Anti-Inflammatory Agents
Cytokines
Newborn Animals
Asphyxia
Wounds and Injuries
Brain Diseases
Brain Ischemia
Cause of Death
Animal Models
Clinical Trials
Newborn Infant
Inflammation

Keywords

  • Chemokines
  • Cytokines
  • Inflammatory mediators
  • Paediatric stroke

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

Cite this

Mirabelli-Badenier, M., Braunersreuther, V., Lenglet, S., Galan, K., Veneselli, E., Viviani, G. L., ... Montecucco, F. (2012). Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury. European Journal of Clinical Investigation, 42(7), 784-794. https://doi.org/10.1111/j.1365-2362.2012.02640.x

Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury. / Mirabelli-Badenier, Marisol; Braunersreuther, Vincent; Lenglet, Sébastien; Galan, Katia; Veneselli, Edvige; Viviani, Giorgio L.; Mach, François; Montecucco, Fabrizio.

In: European Journal of Clinical Investigation, Vol. 42, No. 7, 07.2012, p. 784-794.

Research output: Contribution to journalArticle

Mirabelli-Badenier, M, Braunersreuther, V, Lenglet, S, Galan, K, Veneselli, E, Viviani, GL, Mach, F & Montecucco, F 2012, 'Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury', European Journal of Clinical Investigation, vol. 42, no. 7, pp. 784-794. https://doi.org/10.1111/j.1365-2362.2012.02640.x
Mirabelli-Badenier, Marisol ; Braunersreuther, Vincent ; Lenglet, Sébastien ; Galan, Katia ; Veneselli, Edvige ; Viviani, Giorgio L. ; Mach, François ; Montecucco, Fabrizio. / Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury. In: European Journal of Clinical Investigation. 2012 ; Vol. 42, No. 7. pp. 784-794.
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