Pathophysiologically relevant in vitro tumor models for drug screening

Viswanath Das, Francesca Bruzzese, Petr Konečný, Federica Iannelli, Alfredo Budillon, Marián Hajdúch

Research output: Contribution to journalArticlepeer-review

Abstract

The alarming rate of failure of clinical trials is a major hurdle in cancer therapy that partly results from the inadequate use of in vitro tumor models for the screening of promising hits and leads in preclinical studies. 2D cultures of cancer cell lines that are primarily used for drug screening do not adequately recapitulate tumor microenvironment (TME) complexities compared with 3D cancer cell cultures and tumor-derived primary cell cultures. In this review, we focus on the potential use of in vitro tumor models that reproduce in vivo tumor complexities for effective drug selection in the preclinical stages of drug development.

Original languageEnglish
Article number1610
Pages (from-to)848-855
Number of pages8
JournalDrug Discovery Today
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 9 2015

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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