Pathophysiology and diagnosis of hibernating myocardium in patients with post-ischemic heart failure: The contribution of PET

Paolo G. Camici, Ornella E. Rimoldi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar. There are few data on patients with severe LV dysfunction and heart failure in whom the greatest benefits are apparent after revascularization. Quantification of FDG uptake with PET during hyperinsulinemic euglycemic clamp is accurate in these patients with the greatest mortality risk in whom other techniques may give high false negative rates. The debate on whether resting myocardial blood flow to HM is reduced or not has stimulated new research on heart failure in patients with coronary artery disease. PET with H215O or 13NH 3 has been used for the absolute quantification of regional blood flow in human HM. When HM is properly identified, resting blood flow is not different from that in healthy volunteers although a reduction of ∼20% can be demonstrated in a minority of cases. PET studies have shown that the main feature of HM is a severe impairment of coronary vasodilator reserve that improves after revascularization in parallel with LV function. Thus, the pathophysiology of HM is more complex than initially postulated. The recent evidence that repetitive ischemia in patients can be cumulative and lead to more severe and prolonged stunning, lends further support to the hypothesis that, at least initially, stunning and HM are two facets of the same coin.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalAnnals of Nuclear Medicine
Volume17
Issue number5
Publication statusPublished - Jul 2003

Fingerprint

Myocardium
Heart Failure
Numismatics
Glucose Clamp Technique
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Vasodilator Agents
Echocardiography
Coronary Artery Disease
Healthy Volunteers
Ischemia
Mortality
Research

Keywords

  • Congestive heart failure
  • Coronary artery disease
  • Myocardial blood flow
  • Myocardial metabolism
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Pathophysiology and diagnosis of hibernating myocardium in patients with post-ischemic heart failure : The contribution of PET. / Camici, Paolo G.; Rimoldi, Ornella E.

In: Annals of Nuclear Medicine, Vol. 17, No. 5, 07.2003, p. 341-350.

Research output: Contribution to journalArticle

@article{834d0c43b8144bee917b86a9d30dd42a,
title = "Pathophysiology and diagnosis of hibernating myocardium in patients with post-ischemic heart failure: The contribution of PET",
abstract = "Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar. There are few data on patients with severe LV dysfunction and heart failure in whom the greatest benefits are apparent after revascularization. Quantification of FDG uptake with PET during hyperinsulinemic euglycemic clamp is accurate in these patients with the greatest mortality risk in whom other techniques may give high false negative rates. The debate on whether resting myocardial blood flow to HM is reduced or not has stimulated new research on heart failure in patients with coronary artery disease. PET with H215O or 13NH 3 has been used for the absolute quantification of regional blood flow in human HM. When HM is properly identified, resting blood flow is not different from that in healthy volunteers although a reduction of ∼20{\%} can be demonstrated in a minority of cases. PET studies have shown that the main feature of HM is a severe impairment of coronary vasodilator reserve that improves after revascularization in parallel with LV function. Thus, the pathophysiology of HM is more complex than initially postulated. The recent evidence that repetitive ischemia in patients can be cumulative and lead to more severe and prolonged stunning, lends further support to the hypothesis that, at least initially, stunning and HM are two facets of the same coin.",
keywords = "Congestive heart failure, Coronary artery disease, Myocardial blood flow, Myocardial metabolism, Positron emission tomography",
author = "Camici, {Paolo G.} and Rimoldi, {Ornella E.}",
year = "2003",
month = "7",
language = "English",
volume = "17",
pages = "341--350",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - Pathophysiology and diagnosis of hibernating myocardium in patients with post-ischemic heart failure

T2 - The contribution of PET

AU - Camici, Paolo G.

AU - Rimoldi, Ornella E.

PY - 2003/7

Y1 - 2003/7

N2 - Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar. There are few data on patients with severe LV dysfunction and heart failure in whom the greatest benefits are apparent after revascularization. Quantification of FDG uptake with PET during hyperinsulinemic euglycemic clamp is accurate in these patients with the greatest mortality risk in whom other techniques may give high false negative rates. The debate on whether resting myocardial blood flow to HM is reduced or not has stimulated new research on heart failure in patients with coronary artery disease. PET with H215O or 13NH 3 has been used for the absolute quantification of regional blood flow in human HM. When HM is properly identified, resting blood flow is not different from that in healthy volunteers although a reduction of ∼20% can be demonstrated in a minority of cases. PET studies have shown that the main feature of HM is a severe impairment of coronary vasodilator reserve that improves after revascularization in parallel with LV function. Thus, the pathophysiology of HM is more complex than initially postulated. The recent evidence that repetitive ischemia in patients can be cumulative and lead to more severe and prolonged stunning, lends further support to the hypothesis that, at least initially, stunning and HM are two facets of the same coin.

AB - Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar. There are few data on patients with severe LV dysfunction and heart failure in whom the greatest benefits are apparent after revascularization. Quantification of FDG uptake with PET during hyperinsulinemic euglycemic clamp is accurate in these patients with the greatest mortality risk in whom other techniques may give high false negative rates. The debate on whether resting myocardial blood flow to HM is reduced or not has stimulated new research on heart failure in patients with coronary artery disease. PET with H215O or 13NH 3 has been used for the absolute quantification of regional blood flow in human HM. When HM is properly identified, resting blood flow is not different from that in healthy volunteers although a reduction of ∼20% can be demonstrated in a minority of cases. PET studies have shown that the main feature of HM is a severe impairment of coronary vasodilator reserve that improves after revascularization in parallel with LV function. Thus, the pathophysiology of HM is more complex than initially postulated. The recent evidence that repetitive ischemia in patients can be cumulative and lead to more severe and prolonged stunning, lends further support to the hypothesis that, at least initially, stunning and HM are two facets of the same coin.

KW - Congestive heart failure

KW - Coronary artery disease

KW - Myocardial blood flow

KW - Myocardial metabolism

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0041317721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041317721&partnerID=8YFLogxK

M3 - Article

C2 - 12971630

AN - SCOPUS:0041317721

VL - 17

SP - 341

EP - 350

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 5

ER -