Pathophysiology and treatment of alveolar-capillary dysfunction in chronic heart failure

Research output: Contribution to journalArticle

Abstract

Heart failure increases the resistance to gas transfer across the alveolar-capillary membrane. Disruption of the alveolar anatomical configuration and impairment of cellular pathways involved in the fluid-flux regulation and gas-exchange efficiency (i.e., 'stress failure' of the alveolar-capillary membrane) has been well characterized in different experimental settings of vascular-capillary injury. In heart failure, the appreciation of the pathophysiologic relevance of alveolar stress failure continues to grow. Alveolar-capillary membrane conductance and capillary blood volume are the subcomponents of lung-diffusion capacity. An alveolar-capillary membrane conductance reduction with a trend of capillary blood volume to increase and with consequent impairment of gas exchange, are typical of the heart-failure syndrome. Alveolar-capillary membrane conductance abnormalities have been shown to reflect the underlying lung-tissue damage, to bring an independent prognostic information and to play a significant role in the pathogenesis of exercise limitation and ventilatory abnormalities. This review focuses on the current knowledge on this topic.

Original languageEnglish
Pages (from-to)641-648
Number of pages8
JournalTherapy
Volume2
Issue number4
DOIs
Publication statusPublished - Jul 2005

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Heart Failure
Membranes
Gases
Therapeutics
Blood Volume
Lung Volume Measurements
Vascular System Injuries
Lung

Keywords

  • Alveolar-capillary dysfunction
  • Capillary blood volume
  • DLco
  • Heart failue

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Pathophysiology and treatment of alveolar-capillary dysfunction in chronic heart failure. / Guazzi, Marco.

In: Therapy, Vol. 2, No. 4, 07.2005, p. 641-648.

Research output: Contribution to journalArticle

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