Abstract
Heart failure increases the resistance to gas transfer across the alveolar-capillary membrane. Disruption of the alveolar anatomical configuration and impairment of cellular pathways involved in the fluid-flux regulation and gas-exchange efficiency (i.e., 'stress failure' of the alveolar-capillary membrane) has been well characterized in different experimental settings of vascular-capillary injury. In heart failure, the appreciation of the pathophysiologic relevance of alveolar stress failure continues to grow. Alveolar-capillary membrane conductance and capillary blood volume are the subcomponents of lung-diffusion capacity. An alveolar-capillary membrane conductance reduction with a trend of capillary blood volume to increase and with consequent impairment of gas exchange, are typical of the heart-failure syndrome. Alveolar-capillary membrane conductance abnormalities have been shown to reflect the underlying lung-tissue damage, to bring an independent prognostic information and to play a significant role in the pathogenesis of exercise limitation and ventilatory abnormalities. This review focuses on the current knowledge on this topic.
| Original language | English |
|---|---|
| Pages (from-to) | 641-648 |
| Number of pages | 8 |
| Journal | Therapy |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2005 |
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Keywords
- Alveolar-capillary dysfunction
- Capillary blood volume
- DLco
- Heart failue
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Pathophysiology and treatment of alveolar-capillary dysfunction in chronic heart failure. / Guazzi, Marco.
In: Therapy, Vol. 2, No. 4, 07.2005, p. 641-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology and treatment of alveolar-capillary dysfunction in chronic heart failure
AU - Guazzi, Marco
PY - 2005/7
Y1 - 2005/7
N2 - Heart failure increases the resistance to gas transfer across the alveolar-capillary membrane. Disruption of the alveolar anatomical configuration and impairment of cellular pathways involved in the fluid-flux regulation and gas-exchange efficiency (i.e., 'stress failure' of the alveolar-capillary membrane) has been well characterized in different experimental settings of vascular-capillary injury. In heart failure, the appreciation of the pathophysiologic relevance of alveolar stress failure continues to grow. Alveolar-capillary membrane conductance and capillary blood volume are the subcomponents of lung-diffusion capacity. An alveolar-capillary membrane conductance reduction with a trend of capillary blood volume to increase and with consequent impairment of gas exchange, are typical of the heart-failure syndrome. Alveolar-capillary membrane conductance abnormalities have been shown to reflect the underlying lung-tissue damage, to bring an independent prognostic information and to play a significant role in the pathogenesis of exercise limitation and ventilatory abnormalities. This review focuses on the current knowledge on this topic.
AB - Heart failure increases the resistance to gas transfer across the alveolar-capillary membrane. Disruption of the alveolar anatomical configuration and impairment of cellular pathways involved in the fluid-flux regulation and gas-exchange efficiency (i.e., 'stress failure' of the alveolar-capillary membrane) has been well characterized in different experimental settings of vascular-capillary injury. In heart failure, the appreciation of the pathophysiologic relevance of alveolar stress failure continues to grow. Alveolar-capillary membrane conductance and capillary blood volume are the subcomponents of lung-diffusion capacity. An alveolar-capillary membrane conductance reduction with a trend of capillary blood volume to increase and with consequent impairment of gas exchange, are typical of the heart-failure syndrome. Alveolar-capillary membrane conductance abnormalities have been shown to reflect the underlying lung-tissue damage, to bring an independent prognostic information and to play a significant role in the pathogenesis of exercise limitation and ventilatory abnormalities. This review focuses on the current knowledge on this topic.
KW - Alveolar-capillary dysfunction
KW - Capillary blood volume
KW - DLco
KW - Heart failue
UR - http://www.scopus.com/inward/record.url?scp=22544451833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22544451833&partnerID=8YFLogxK
U2 - 10.1586/14750708.2.4.641
DO - 10.1586/14750708.2.4.641
M3 - Article
AN - SCOPUS:22544451833
VL - 2
SP - 641
EP - 648
JO - Therapy
JF - Therapy
SN - 1475-0708
IS - 4
ER -