Pathophysiology of conduction block in multifocal motor neuropathy

G. Ardolino, B. Bossi, S. Barbieri, E. Nobile-Orazio, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Multifocal motor neuropathy (MMN) is a rare disorder of the peripheral nervous system characterised by the presence of focal motor conduction blocks. Although the pathological basis of conduction block is believed to be focal demyelination, in multifocal motor neuropathy this mechanism lacks definitive proof from morphological studies. In recent years special neurophysiological techniques for assessing axonal excitability non-invasively in humans have expanded knowledge on the pathophysiology of multifocal motor neuropathy. Nonetheless, several findings support the hypothesis that conduction blocks probably arise from more than one pathogenetic mechanism (hyperpolarisation or depolarisation) which can change during the course of the disease and probably represent the "tip of the iceberg" of axo-myelinic abnormalities.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalSchweizer Archiv fur Neurologie und Psychiatrie
Volume158
Issue number2
Publication statusPublished - Feb 2007

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Keywords

  • Conduction block
  • Depolarisation
  • Hyperpolarisation
  • Multifocal motor neuropathy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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