Fisiopatologia della nefropatia da mezzo di contrasto

Translated title of the contribution: Pathophysiology of contrast-induced nephropathy

Carlo Guastoni, Stefano De Servi

Research output: Contribution to journalArticlepeer-review


Contrast-induced nephropathy is one of the major causes of kidney failure in hospitalized patients. Its increased frequency is due to the high number of invasive procedures using contrast media performed for diagnostic or therapeutic purposes in patients with cardiovascular diseases with advanced age and chronic comorbidities such as diabetes and preexisting renal failure. There are two main causes of contrast-induced nephropathy: the direct toxic effect of contrast media on kidney tubules (as shown by morphologic alterations of these cells) and the tissue hypoxia of the renal medulla, secondary to the hemodynamic effects brought about by these agents, consisting in a reduction of vascular resistances. In vulnerable patients, these vasoconstrictor effects are not balanced by an effective vasodilatory reserve and probably by a reduced production of antiapoptotic proteins.

Translated title of the contributionPathophysiology of contrast-induced nephropathy
Original languageItalian
Pages (from-to)73-78
Number of pages6
JournalGiornale Italiano di Cardiologia
Issue number2
Publication statusPublished - Feb 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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