Patofisiologia della malattia da reflusso gastroesofageo

Translated title of the contribution: Pathophysiology of gastro-oesophageal reflux disease

R. Penagini, M. Mangano

Research output: Contribution to journalArticlepeer-review


Recent technological developments have allowed to better understand the pathogenesis of gastro-oesophageal reflux disease. The increased oesophageal acid exposure is due to a number of functional and anatomical factors variously combined in each patient. Transient lower oesophageal sphincter relaxation, which is the physiological mechanism of belching, is the major motor event underlying reflux in most patients. Presence of a hiatal hernia may play an important role, both in promoting reflux and in delaying clearance. Peristaltic dysfunction leading to impaired acid clearance is frequent especially in severe oesophagitis. Oesophageal hypersensitivity to acid is often present and is the only pathophysiological factor in some of the patients. The role of mucosal defence in prevention of oesophagitis is still uncertain.

Translated title of the contributionPathophysiology of gastro-oesophageal reflux disease
Original languageItalian
Pages (from-to)189-192
Number of pages4
JournalGiornale Italiano di Endoscopia Digestiva
Issue number4
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Gastroenterology


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