Recent technological developments have allowed to better understand the pathogenesis of gastro-oesophageal reflux disease. The increased oesophageal acid exposure is due to a number of functional and anatomical factors variously combined in each patient. Transient lower oesophageal sphincter relaxation, which is the physiological mechanism of belching, is the major motor event underlying reflux in most patients. Presence of a hiatal hernia may play an important role, both in promoting reflux and in delaying clearance. Peristaltic dysfunction leading to impaired acid clearance is frequent especially in severe oesophagitis. Oesophageal hypersensitivity to acid is often present and is the only pathophysiological factor in some of the patients. The role of mucosal defence in prevention of oesophagitis is still uncertain.
|Translated title of the contribution||Pathophysiology of gastro-oesophageal reflux disease|
|Number of pages||4|
|Journal||Giornale Italiano di Endoscopia Digestiva|
|Publication status||Published - 1998|
ASJC Scopus subject areas