Patofisiologia della malattia da reflusso gastroesofageo

Translated title of the contribution: Pathophysiology of gastro-oesophageal reflux disease

R. Penagini, M. Mangano

Research output: Contribution to journalArticle

Abstract

Recent technological developments have allowed to better understand the pathogenesis of gastro-oesophageal reflux disease. The increased oesophageal acid exposure is due to a number of functional and anatomical factors variously combined in each patient. Transient lower oesophageal sphincter relaxation, which is the physiological mechanism of belching, is the major motor event underlying reflux in most patients. Presence of a hiatal hernia may play an important role, both in promoting reflux and in delaying clearance. Peristaltic dysfunction leading to impaired acid clearance is frequent especially in severe oesophagitis. Oesophageal hypersensitivity to acid is often present and is the only pathophysiological factor in some of the patients. The role of mucosal defence in prevention of oesophagitis is still uncertain.

Original languageItalian
Pages (from-to)189-192
Number of pages4
JournalGiornale Italiano di Endoscopia Digestiva
Volume21
Issue number4
Publication statusPublished - 1998

Fingerprint

Esophageal Diseases
Gastroesophageal Reflux
Esophagitis
Acids
Eructation
Lower Esophageal Sphincter
Hiatal Hernia
Hypersensitivity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Patofisiologia della malattia da reflusso gastroesofageo. / Penagini, R.; Mangano, M.

In: Giornale Italiano di Endoscopia Digestiva, Vol. 21, No. 4, 1998, p. 189-192.

Research output: Contribution to journalArticle

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