Pathophysiology of non alcoholic fatty liver disease

Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino

Research output: Contribution to journalReview articlepeer-review


The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

Original languageEnglish
Article number2082
JournalInternational Journal of Molecular Sciences
Issue number12
Publication statusPublished - Dec 11 2016


  • Adiponectin
  • Cholesterol
  • Fatty liver
  • Free fatty acids
  • Ghrelin
  • Glucagon
  • Glucagon-like peptide 1
  • Insulin
  • Insulin resistance
  • Irisin
  • Leptin
  • Selenoprotein P

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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