Pathophysiology of the human intervertebral disc

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Intervertebral disc degeneration is a common invalidating disorder that can affect the musculoskeletal apparatus in both younger and older ages. The chief component of the intervertebral disc is the highly organized extracellular matrix; maintenance of its organization is essential for correct spinal mechanics. The matrix components, mainly proteoglycans and collagens, undergo a slow and continuous cell-mediated turnover process that enables disc cells to adapt their environment to external stimuli. Cellular senescence and a history of chronic abnormal loading can upset this balance, leading to progressive tissue failure that results in disc degeneration. Although biological treatment approaches to disc repair are still far to come, advances in our understanding of disc biochemistry and in defining the role of genetic inheritance have provided a starting point for developing new concepts in the diagnosis, therapy and prevention of disc degeneration.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume40
Issue number5
DOIs
Publication statusPublished - 2008

Fingerprint

Intervertebral Disc Degeneration
Biochemistry
Intervertebral Disc
Proteoglycans
Mechanics
Repair
Collagen
Tissue
Cell Aging
Extracellular Matrix
Maintenance
Therapeutics

Keywords

  • Collagens
  • Extracellular matrix turnover
  • Intervertebral disc degeneration
  • Proteoglycans

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

@article{042aaeed2cdb47f9a2c4a7ab1751db0b,
title = "Pathophysiology of the human intervertebral disc",
abstract = "Intervertebral disc degeneration is a common invalidating disorder that can affect the musculoskeletal apparatus in both younger and older ages. The chief component of the intervertebral disc is the highly organized extracellular matrix; maintenance of its organization is essential for correct spinal mechanics. The matrix components, mainly proteoglycans and collagens, undergo a slow and continuous cell-mediated turnover process that enables disc cells to adapt their environment to external stimuli. Cellular senescence and a history of chronic abnormal loading can upset this balance, leading to progressive tissue failure that results in disc degeneration. Although biological treatment approaches to disc repair are still far to come, advances in our understanding of disc biochemistry and in defining the role of genetic inheritance have provided a starting point for developing new concepts in the diagnosis, therapy and prevention of disc degeneration.",
keywords = "Collagens, Extracellular matrix turnover, Intervertebral disc degeneration, Proteoglycans",
author = "Alessandra Colombini and Giovanni Lombardi and Corsi, {Massimiliano Marco} and Giuseppe Banfi",
year = "2008",
doi = "10.1016/j.biocel.2007.12.011",
language = "English",
volume = "40",
pages = "837--842",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Pathophysiology of the human intervertebral disc

AU - Colombini, Alessandra

AU - Lombardi, Giovanni

AU - Corsi, Massimiliano Marco

AU - Banfi, Giuseppe

PY - 2008

Y1 - 2008

N2 - Intervertebral disc degeneration is a common invalidating disorder that can affect the musculoskeletal apparatus in both younger and older ages. The chief component of the intervertebral disc is the highly organized extracellular matrix; maintenance of its organization is essential for correct spinal mechanics. The matrix components, mainly proteoglycans and collagens, undergo a slow and continuous cell-mediated turnover process that enables disc cells to adapt their environment to external stimuli. Cellular senescence and a history of chronic abnormal loading can upset this balance, leading to progressive tissue failure that results in disc degeneration. Although biological treatment approaches to disc repair are still far to come, advances in our understanding of disc biochemistry and in defining the role of genetic inheritance have provided a starting point for developing new concepts in the diagnosis, therapy and prevention of disc degeneration.

AB - Intervertebral disc degeneration is a common invalidating disorder that can affect the musculoskeletal apparatus in both younger and older ages. The chief component of the intervertebral disc is the highly organized extracellular matrix; maintenance of its organization is essential for correct spinal mechanics. The matrix components, mainly proteoglycans and collagens, undergo a slow and continuous cell-mediated turnover process that enables disc cells to adapt their environment to external stimuli. Cellular senescence and a history of chronic abnormal loading can upset this balance, leading to progressive tissue failure that results in disc degeneration. Although biological treatment approaches to disc repair are still far to come, advances in our understanding of disc biochemistry and in defining the role of genetic inheritance have provided a starting point for developing new concepts in the diagnosis, therapy and prevention of disc degeneration.

KW - Collagens

KW - Extracellular matrix turnover

KW - Intervertebral disc degeneration

KW - Proteoglycans

UR - http://www.scopus.com/inward/record.url?scp=40149098318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40149098318&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2007.12.011

DO - 10.1016/j.biocel.2007.12.011

M3 - Article

C2 - 18243770

AN - SCOPUS:40149098318

VL - 40

SP - 837

EP - 842

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 5

ER -