Myoclonic jerks can occur in several neurological diseases at rest or during voluntary movements (intention and action myoclonus). The study of stimulus-sensitive or 'reflex' type of myoclonus has considerably advanced out understanding of its pathophysiology. By the combination of different stimulation and recording techniques (namely the jerk-locked averaging) different types of myclonus has been characterized, i.e. cortical and reticular reflex myoclonus. Recent results suggest that an inhibitory component of the myoclonus (sometimes seen in isolation: 'negative myoclonus') is due to the involvement of premotor inhibitory cortex. Myoclonic jerks are observed in several epileptic syndromes: a detailed neurophysiological study can significantly contribute to improve our understanding of the underlying pathophysiological mechanisms.
|Translated title of the contribution||Pathophysiology of the myoclonus|
|Number of pages||5|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Clinical Neurology