Pathophysiology of tics and Tourette syndrome

Alfredo Berardelli, Antonio Currà, Giovanni Fabbrini, Francesca Gilio, Mario Manfredi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Tics are involuntary movements that can affect one or more muscles producing simple or complex movements. Blink reflex and startle reflex studies disclose an increased excitability of brainstem interneurons. Analysis of voluntary movement shows that when advance visual information is reduced, patients with tics and Tourette syndrome become progressively slower in completing motor sequences. Sensorimotor integration is abnormally processed. Studies of the contingent negative variation demonstrate abnormalities of movement preparation and the investigation of premotor potentials shows that in some patients tics are not preceded by a normal premotor potential. Magnetic stimulation studies demonstrate an increased excitability of cortical motor cortex. Functional MRI, PET and SPECT studies show abnormal activation of cortical and subcortical areas. Dysfunction of basal ganglia-thalamo-cortical projections affects sensorimotor, language and limbic cortical circuits, and may explain why patients with Tourette syndrome have difficulty in inhibiting unwanted behaviors and impulses.

Original languageEnglish
Pages (from-to)781-787
Number of pages7
JournalJournal of Neurology
Volume250
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

Fingerprint

Tics
Tourette Syndrome
Startle Reflex
Contingent Negative Variation
Blinking
Dyskinesias
Motor Cortex
Interneurons
Basal Ganglia
Single-Photon Emission-Computed Tomography
Brain Stem
Language
Magnetic Resonance Imaging
Muscles

Keywords

  • Motor disturbances
  • Tics
  • Tourette syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pathophysiology of tics and Tourette syndrome. / Berardelli, Alfredo; Currà, Antonio; Fabbrini, Giovanni; Gilio, Francesca; Manfredi, Mario.

In: Journal of Neurology, Vol. 250, No. 7, 01.07.2003, p. 781-787.

Research output: Contribution to journalArticle

Berardelli, Alfredo ; Currà, Antonio ; Fabbrini, Giovanni ; Gilio, Francesca ; Manfredi, Mario. / Pathophysiology of tics and Tourette syndrome. In: Journal of Neurology. 2003 ; Vol. 250, No. 7. pp. 781-787.
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