Pathophysiology of tobacco smoke exposure: Recent insights from comparative and redox proteomics

Graziano Colombo, Marco Clerici, Daniela Giustarini, Nicola M. Portinaro, Giancarlo Aldini, Ranieri Rossi, Aldo Milzani, Isabella Dalle-Donne

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

First-hand and second-hand tobacco smoke are causally linked to a huge number of deaths and are responsible for a broad spectrum of pathologies such as cancer, cardiovascular, respiratory, and eye diseases as well as adverse effects on female reproductive function. Cigarette smoke is a complex mixture of thousands of different chemical species, which exert their negative effects on macromolecules and biochemical pathways, both directly and indirectly. Many compounds can act as oxidants, pro-inflammatory agents, carcinogens, or a combination of these. The redox behavior of cigarette smoke has many implications for smoke related diseases. Reactive oxygen and nitrogen species (both radicals and non-radicals), reactive carbonyl compounds, and other species may induce oxidative damage in almost all the biological macromolecules, compromising their structure and/or function. Different quantitative and redox proteomic approaches have been applied in vitro and in vivo to evaluate, respectively, changes in protein expression and specific oxidative protein modifications induced by exposure to cigarette smoke and are overviewed in this review. Many gel-based and gel-free proteomic techniques have already been used successfully to obtain clues about smoke effects on different proteins in cell cultures, animal models, and humans. The further implementation with other sensitive screening techniques could be useful to integrate the comprehension of cigarette smoke effects on human health. In particular, the redox proteomic approach may also help identify biomarkers of exposure to tobacco smoke useful for preventing these effects or potentially predictive of the onset and/or progression of smoking-induced diseases as well as potential targets for therapeutic strategies.

Original languageEnglish
Pages (from-to)183-218
Number of pages36
JournalMass Spectrometry Reviews
Volume33
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

tobacco
Tobacco
smoke
Smoke
Proteomics
Oxidation-Reduction
Tobacco Products
proteins
Macromolecules
macromolecules
Gels
Animal cell culture
eye diseases
respiratory diseases
Reactive Nitrogen Species
gels
Tobacco Smoke Pollution
Proteins
carcinogens
Eye Diseases

Keywords

  • (redox) proteomics
  • inflammation
  • mass spectrometry
  • oxidative modifications
  • protein oxidation
  • tobacco smoke

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Analytical Chemistry
  • Spectroscopy
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Pathophysiology of tobacco smoke exposure : Recent insights from comparative and redox proteomics. / Colombo, Graziano; Clerici, Marco; Giustarini, Daniela; Portinaro, Nicola M.; Aldini, Giancarlo; Rossi, Ranieri; Milzani, Aldo; Dalle-Donne, Isabella.

In: Mass Spectrometry Reviews, Vol. 33, No. 3, 2014, p. 183-218.

Research output: Contribution to journalArticle

Colombo, G, Clerici, M, Giustarini, D, Portinaro, NM, Aldini, G, Rossi, R, Milzani, A & Dalle-Donne, I 2014, 'Pathophysiology of tobacco smoke exposure: Recent insights from comparative and redox proteomics', Mass Spectrometry Reviews, vol. 33, no. 3, pp. 183-218. https://doi.org/10.1002/mas.21392
Colombo, Graziano ; Clerici, Marco ; Giustarini, Daniela ; Portinaro, Nicola M. ; Aldini, Giancarlo ; Rossi, Ranieri ; Milzani, Aldo ; Dalle-Donne, Isabella. / Pathophysiology of tobacco smoke exposure : Recent insights from comparative and redox proteomics. In: Mass Spectrometry Reviews. 2014 ; Vol. 33, No. 3. pp. 183-218.
@article{9d6f5cb6ed334fed95d8e34934a7837a,
title = "Pathophysiology of tobacco smoke exposure: Recent insights from comparative and redox proteomics",
abstract = "First-hand and second-hand tobacco smoke are causally linked to a huge number of deaths and are responsible for a broad spectrum of pathologies such as cancer, cardiovascular, respiratory, and eye diseases as well as adverse effects on female reproductive function. Cigarette smoke is a complex mixture of thousands of different chemical species, which exert their negative effects on macromolecules and biochemical pathways, both directly and indirectly. Many compounds can act as oxidants, pro-inflammatory agents, carcinogens, or a combination of these. The redox behavior of cigarette smoke has many implications for smoke related diseases. Reactive oxygen and nitrogen species (both radicals and non-radicals), reactive carbonyl compounds, and other species may induce oxidative damage in almost all the biological macromolecules, compromising their structure and/or function. Different quantitative and redox proteomic approaches have been applied in vitro and in vivo to evaluate, respectively, changes in protein expression and specific oxidative protein modifications induced by exposure to cigarette smoke and are overviewed in this review. Many gel-based and gel-free proteomic techniques have already been used successfully to obtain clues about smoke effects on different proteins in cell cultures, animal models, and humans. The further implementation with other sensitive screening techniques could be useful to integrate the comprehension of cigarette smoke effects on human health. In particular, the redox proteomic approach may also help identify biomarkers of exposure to tobacco smoke useful for preventing these effects or potentially predictive of the onset and/or progression of smoking-induced diseases as well as potential targets for therapeutic strategies.",
keywords = "(redox) proteomics, inflammation, mass spectrometry, oxidative modifications, protein oxidation, tobacco smoke",
author = "Graziano Colombo and Marco Clerici and Daniela Giustarini and Portinaro, {Nicola M.} and Giancarlo Aldini and Ranieri Rossi and Aldo Milzani and Isabella Dalle-Donne",
year = "2014",
doi = "10.1002/mas.21392",
language = "English",
volume = "33",
pages = "183--218",
journal = "Mass Spectrometry Reviews",
issn = "0277-7037",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Pathophysiology of tobacco smoke exposure

T2 - Recent insights from comparative and redox proteomics

AU - Colombo, Graziano

AU - Clerici, Marco

AU - Giustarini, Daniela

AU - Portinaro, Nicola M.

AU - Aldini, Giancarlo

AU - Rossi, Ranieri

AU - Milzani, Aldo

AU - Dalle-Donne, Isabella

PY - 2014

Y1 - 2014

N2 - First-hand and second-hand tobacco smoke are causally linked to a huge number of deaths and are responsible for a broad spectrum of pathologies such as cancer, cardiovascular, respiratory, and eye diseases as well as adverse effects on female reproductive function. Cigarette smoke is a complex mixture of thousands of different chemical species, which exert their negative effects on macromolecules and biochemical pathways, both directly and indirectly. Many compounds can act as oxidants, pro-inflammatory agents, carcinogens, or a combination of these. The redox behavior of cigarette smoke has many implications for smoke related diseases. Reactive oxygen and nitrogen species (both radicals and non-radicals), reactive carbonyl compounds, and other species may induce oxidative damage in almost all the biological macromolecules, compromising their structure and/or function. Different quantitative and redox proteomic approaches have been applied in vitro and in vivo to evaluate, respectively, changes in protein expression and specific oxidative protein modifications induced by exposure to cigarette smoke and are overviewed in this review. Many gel-based and gel-free proteomic techniques have already been used successfully to obtain clues about smoke effects on different proteins in cell cultures, animal models, and humans. The further implementation with other sensitive screening techniques could be useful to integrate the comprehension of cigarette smoke effects on human health. In particular, the redox proteomic approach may also help identify biomarkers of exposure to tobacco smoke useful for preventing these effects or potentially predictive of the onset and/or progression of smoking-induced diseases as well as potential targets for therapeutic strategies.

AB - First-hand and second-hand tobacco smoke are causally linked to a huge number of deaths and are responsible for a broad spectrum of pathologies such as cancer, cardiovascular, respiratory, and eye diseases as well as adverse effects on female reproductive function. Cigarette smoke is a complex mixture of thousands of different chemical species, which exert their negative effects on macromolecules and biochemical pathways, both directly and indirectly. Many compounds can act as oxidants, pro-inflammatory agents, carcinogens, or a combination of these. The redox behavior of cigarette smoke has many implications for smoke related diseases. Reactive oxygen and nitrogen species (both radicals and non-radicals), reactive carbonyl compounds, and other species may induce oxidative damage in almost all the biological macromolecules, compromising their structure and/or function. Different quantitative and redox proteomic approaches have been applied in vitro and in vivo to evaluate, respectively, changes in protein expression and specific oxidative protein modifications induced by exposure to cigarette smoke and are overviewed in this review. Many gel-based and gel-free proteomic techniques have already been used successfully to obtain clues about smoke effects on different proteins in cell cultures, animal models, and humans. The further implementation with other sensitive screening techniques could be useful to integrate the comprehension of cigarette smoke effects on human health. In particular, the redox proteomic approach may also help identify biomarkers of exposure to tobacco smoke useful for preventing these effects or potentially predictive of the onset and/or progression of smoking-induced diseases as well as potential targets for therapeutic strategies.

KW - (redox) proteomics

KW - inflammation

KW - mass spectrometry

KW - oxidative modifications

KW - protein oxidation

KW - tobacco smoke

UR - http://www.scopus.com/inward/record.url?scp=84897912027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897912027&partnerID=8YFLogxK

U2 - 10.1002/mas.21392

DO - 10.1002/mas.21392

M3 - Article

C2 - 24272816

AN - SCOPUS:84897912027

VL - 33

SP - 183

EP - 218

JO - Mass Spectrometry Reviews

JF - Mass Spectrometry Reviews

SN - 0277-7037

IS - 3

ER -