Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives

Silvana Galderisi, Alessandro Rossi, Paola Rocca, Alessandro Bertolino, Armida Mucci, Paola Bucci, Paola Rucci, Dino Gibertoni, Eugenio Aguglia, Mario Amore, Giuseppe Blasi, Anna Comparelli, Massimo Di Giannantonio, Arianna Goracci, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Federica Pinna, Rita Roncone, Alberto SiracusanoPaolo Stratta, Maria Chiara Torti, Antonio Vita, Patrizia Zeppegno, Marcello Chieffi, Mario Maj

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.

Original languageEnglish
JournalSchizophrenia Research
DOIs
Publication statusAccepted/In press - Nov 16 2015

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Schizophrenia
Structural Models
Cognition
Multicenter Studies

Keywords

  • Avolition
  • Cognition
  • Interpersonal relationships
  • Schizophrenia first-degree relatives
  • Structural equation model
  • Work skills

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives. / Galderisi, Silvana; Rossi, Alessandro; Rocca, Paola; Bertolino, Alessandro; Mucci, Armida; Bucci, Paola; Rucci, Paola; Gibertoni, Dino; Aguglia, Eugenio; Amore, Mario; Blasi, Giuseppe; Comparelli, Anna; Di Giannantonio, Massimo; Goracci, Arianna; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Pinna, Federica; Roncone, Rita; Siracusano, Alberto; Stratta, Paolo; Torti, Maria Chiara; Vita, Antonio; Zeppegno, Patrizia; Chieffi, Marcello; Maj, Mario.

In: Schizophrenia Research, 16.11.2015.

Research output: Contribution to journalArticle

Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Blasi, G, Comparelli, A, Di Giannantonio, M, Goracci, A, Marchesi, C, Monteleone, P, Montemagni, C, Pinna, F, Roncone, R, Siracusano, A, Stratta, P, Torti, MC, Vita, A, Zeppegno, P, Chieffi, M & Maj, M 2015, 'Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives', Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.04.043
Galderisi, Silvana ; Rossi, Alessandro ; Rocca, Paola ; Bertolino, Alessandro ; Mucci, Armida ; Bucci, Paola ; Rucci, Paola ; Gibertoni, Dino ; Aguglia, Eugenio ; Amore, Mario ; Blasi, Giuseppe ; Comparelli, Anna ; Di Giannantonio, Massimo ; Goracci, Arianna ; Marchesi, Carlo ; Monteleone, Palmiero ; Montemagni, Cristiana ; Pinna, Federica ; Roncone, Rita ; Siracusano, Alberto ; Stratta, Paolo ; Torti, Maria Chiara ; Vita, Antonio ; Zeppegno, Patrizia ; Chieffi, Marcello ; Maj, Mario. / Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives. In: Schizophrenia Research. 2015.
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abstract = "Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.",
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AU - Galderisi, Silvana

AU - Rossi, Alessandro

AU - Rocca, Paola

AU - Bertolino, Alessandro

AU - Mucci, Armida

AU - Bucci, Paola

AU - Rucci, Paola

AU - Gibertoni, Dino

AU - Aguglia, Eugenio

AU - Amore, Mario

AU - Blasi, Giuseppe

AU - Comparelli, Anna

AU - Di Giannantonio, Massimo

AU - Goracci, Arianna

AU - Marchesi, Carlo

AU - Monteleone, Palmiero

AU - Montemagni, Cristiana

AU - Pinna, Federica

AU - Roncone, Rita

AU - Siracusano, Alberto

AU - Stratta, Paolo

AU - Torti, Maria Chiara

AU - Vita, Antonio

AU - Zeppegno, Patrizia

AU - Chieffi, Marcello

AU - Maj, Mario

PY - 2015/11/16

Y1 - 2015/11/16

N2 - Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.

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KW - Avolition

KW - Cognition

KW - Interpersonal relationships

KW - Schizophrenia first-degree relatives

KW - Structural equation model

KW - Work skills

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