Abstract
Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.
| Original language | English |
|---|---|
| Journal | Schizophrenia Research |
| DOIs | |
| Publication status | Accepted/In press - Nov 16 2015 |
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Keywords
- Avolition
- Cognition
- Interpersonal relationships
- Schizophrenia first-degree relatives
- Structural equation model
- Work skills
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives. / Galderisi, Silvana; Rossi, Alessandro; Rocca, Paola; Bertolino, Alessandro; Mucci, Armida; Bucci, Paola; Rucci, Paola; Gibertoni, Dino; Aguglia, Eugenio; Amore, Mario; Blasi, Giuseppe; Comparelli, Anna; Di Giannantonio, Massimo; Goracci, Arianna; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Pinna, Federica; Roncone, Rita; Siracusano, Alberto; Stratta, Paolo; Torti, Maria Chiara; Vita, Antonio; Zeppegno, Patrizia; Chieffi, Marcello; Maj, Mario.
In: Schizophrenia Research, 16.11.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives
AU - Galderisi, Silvana
AU - Rossi, Alessandro
AU - Rocca, Paola
AU - Bertolino, Alessandro
AU - Mucci, Armida
AU - Bucci, Paola
AU - Rucci, Paola
AU - Gibertoni, Dino
AU - Aguglia, Eugenio
AU - Amore, Mario
AU - Blasi, Giuseppe
AU - Comparelli, Anna
AU - Di Giannantonio, Massimo
AU - Goracci, Arianna
AU - Marchesi, Carlo
AU - Monteleone, Palmiero
AU - Montemagni, Cristiana
AU - Pinna, Federica
AU - Roncone, Rita
AU - Siracusano, Alberto
AU - Stratta, Paolo
AU - Torti, Maria Chiara
AU - Vita, Antonio
AU - Zeppegno, Patrizia
AU - Chieffi, Marcello
AU - Maj, Mario
PY - 2015/11/16
Y1 - 2015/11/16
N2 - Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.
AB - Rationale: Variables influencing real-life functioning have repeatedly been modeled in schizophrenia subjects but not systematically investigated in their unaffected first-degree relatives (SRs), in whom milder forms of deficits reported in schizophrenia have been observed, but confounders of clinical cohorts are not in play. Demonstrating that pathways to functional outcome are similar between patients and SRs would validate structural models developed in schizophrenia subjects. The present multicenter study aimed to explore whether variables associated with real-life functioning are similar in schizophrenia patients and their unaffected relatives. Methods: The study sample included 921 schizophrenia patients, 379 SRs and 780 healthy controls. Structural Equation Models (SEMs) were used in patients and SRs to test associations of psychopathological dimensions, neurocognition, social cognition, resilience, perceived stigma and functional capacity with real-life functioning domains, impaired in both patients and SRs. Results: Interpersonal Relationships and Work Skills were the only functional domains impaired in both patients and SRs. For both domains, functional impairment in patients was found to predict impairment in unaffected relatives, suggesting the involvement of similar illness-related vulnerability factors. In both groups variables significantly associated with Interpersonal Relationships included Social Cognition, Neurocognition, Avolition, Resilience, Disorganization, Perceived Stigma and Gender, and those significantly associated with Work Skills included Social Cognition, Neurocognition and Disorganization. Conclusions: Pathways to functional outcome for Interpersonal relationships and Work skills are similar between schizophrenia patients and their unaffected first-degree relatives. These findings validate, in the absence of confounders of clinical cohorts, structural models of determinants of functional outcome in people with schizophrenia.
KW - Avolition
KW - Cognition
KW - Interpersonal relationships
KW - Schizophrenia first-degree relatives
KW - Structural equation model
KW - Work skills
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UR - http://www.scopus.com/inward/citedby.url?scp=84975505510&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2016.04.043
DO - 10.1016/j.schres.2016.04.043
M3 - Article
AN - SCOPUS:84975505510
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -