Pathways to mitochondrial dysfunction in ALS pathogenesis

Maria Teresa Carrì; Nadia D'Ambrosi; Mauro Cozzolino

doi:10.1016/j.bbrc.2016.07.055

Pathways to mitochondrial dysfunction in ALS pathogenesis

Maria Teresa Carrì, Nadia D'Ambrosi, Mauro Cozzolino

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.

Original language	English
Journal	Biochemical and Biophysical Research Communications
DOIs	https://doi.org/10.1016/j.bbrc.2016.07.055
Publication status	Accepted/In press - Jun 15 2016

Keywords

Alternative splicing
Amyotrophic Lateral Sclerosis
Mitochondria
Mitophagy
Protein aggregation

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2016.07.055

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abstract = "Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.",

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AU - D'Ambrosi, Nadia

AU - Cozzolino, Mauro

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N2 - Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.

AB - Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.

KW - Alternative splicing

KW - Amyotrophic Lateral Sclerosis

KW - Mitochondria

KW - Mitophagy

KW - Protein aggregation

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Pathways to mitochondrial dysfunction in ALS pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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