Pathways to mitochondrial dysfunction in ALS pathogenesis

Maria Teresa Carrì, Nadia D'Ambrosi, Mauro Cozzolino

Research output: Contribution to journalArticle

Abstract

Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.

Original languageEnglish
JournalBiochemical and Biophysical Research Communications
DOIs
Publication statusAccepted/In press - Jun 15 2016

Keywords

  • Alternative splicing
  • Amyotrophic Lateral Sclerosis
  • Mitochondria
  • Mitophagy
  • Protein aggregation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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