Abstract
Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.
| Original language | English |
|---|---|
| Journal | Biochemical and Biophysical Research Communications |
| DOIs | |
| Publication status | Accepted/In press - Jun 15 2016 |
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Keywords
- Alternative splicing
- Amyotrophic Lateral Sclerosis
- Mitochondria
- Mitophagy
- Protein aggregation
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Pathways to mitochondrial dysfunction in ALS pathogenesis. / Carrì, Maria Teresa; D'Ambrosi, Nadia; Cozzolino, Mauro.
In: Biochemical and Biophysical Research Communications, 15.06.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathways to mitochondrial dysfunction in ALS pathogenesis
AU - Carrì, Maria Teresa
AU - D'Ambrosi, Nadia
AU - Cozzolino, Mauro
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.
AB - Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.
KW - Alternative splicing
KW - Amyotrophic Lateral Sclerosis
KW - Mitochondria
KW - Mitophagy
KW - Protein aggregation
UR - http://www.scopus.com/inward/record.url?scp=85002697091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85002697091&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2016.07.055
DO - 10.1016/j.bbrc.2016.07.055
M3 - Article
AN - SCOPUS:85002697091
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
ER -