Abstract
Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process.
Original language | English |
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Journal | Biochemical and Biophysical Research Communications |
DOIs | |
Publication status | Accepted/In press - Jun 15 2016 |
Keywords
- Alternative splicing
- Amyotrophic Lateral Sclerosis
- Mitochondria
- Mitophagy
- Protein aggregation
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology