Patient outcome after complete surgery for retroperitoneal sarcoma

Carlo Riccardo Rossi, Andrea Varotto, Sandro Pasquali, Luca Giovanni Campana, Simone Mocellin, Antonio Sommariva, Maria Cristina Montesco, Marco Rastrelli, Antonella Vecchiato, Pierluigi Pilati, Donato Nitti

Research output: Contribution to journalArticle

Abstract

Background: Aggressive surgery has been suggested for improving local tumor control in patients with retroperitoneal sarcoma (RS). This study aimed at investigating local disease-free and overall survival after complete surgery, in patients with RS. Patients and Methods: Retrospective data of patients submitted to complete surgery for RS were extracted from a prospectively- maintained database. Results: Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%). Patients presenting with recurrent (hazard ratio (HR)=5.57, p=0.002) and high-grade (HR 3.47, p=0.041) tumors were at higher risk of local recurrence. Microscopically-involved tumor resection margins (HR=3.47, p=0.04) and recurrent tumor at presentation (HR=2.49, p=0.008) were independent predictors of poor survival. Conclusion: Patients presenting with primary RS had longer local disease-free survival and overall survival than those with recurrent tumor after complete surgery. Complete surgery remains the standard-of-care for patients with primary RS.

Original languageEnglish
Pages (from-to)4081-4088
Number of pages8
JournalAnticancer Research
Volume33
Issue number9
Publication statusPublished - Sep 2013

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Keywords

  • Disease-free survival
  • Overall survival
  • Retroperitoneal sarcoma
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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